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Hospitalization and Continuity of Care in Anti-MDA5 Dermatomyositis JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-17 William Mark Richardson, Jill T. Shah, Daniel R. Mazori, Avrom S. Caplan, Kristen I. Lo Sicco, Alisa N. Femia
This cohort study describes the clinical features, patient characteristics, and treatment of anti-melanoma differentiation–associated gene 5 (MDA5) dermatomyositis.
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Treatment of Keratosis Lichenoides Chronica With Upadacitinib JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-17 Jingyi Tang, Fang Liu, Wenjun Liao, Guannan Zhu
This case report describes a 30-year-old man presenting with 1-year history of nonitchy red papules and patches who was subsequently treated with upadacitinib.
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Erenumab for Treatment of Persistent Erythema and Flushing in Rosacea JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-17 Nita K. F. Wienholtz, Casper E. Christensen, Thien P. Do, Lith E. W. Frifelt, Josefin Snellman, Cristina L. Lopez-Lopez, Alexander Egeberg, Jacob P. Thyssen, Messoud Ashina
ImportanceTreatment of erythema and flushing in rosacea is challenging. Calcitonin gene-related peptide (CGRP) has been associated with the pathogenesis of rosacea, raising the possibility that inhibition of the CGRP pathway might improve certain features of the disease.ObjectiveTo examine the effectiveness, tolerability, and safety of erenumab, an anti–CGRP-receptor monoclonal antibody, for the treatment
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Chronic Progressive Pink-Yellow Papules and Nodules in a Middle-Aged Man JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-17 Jessica A. Kern, Brian R. Hinds, Veronica Shi
A 38-year-old man presented with numerous pink-yellow firm papules and nodules on the bilateral elbows for 10 years spreading to the hands and knees in the past year. What is your diagnosis?
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Laser and Light-Based Therapies for Hirsutism Management in Women With Polycystic Ovarian Syndrome JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-17 Katrina Tan, Thisara Coster, Aya Mousa, Adrian Mar, Terhi Piltonen, Jacqueline A. Boyle, Helena Teede, Anju Joham, Daniela Romualdi, Chau Thien Tay
ImportanceHirsutism represents a significant concern for women with polycystic ovary syndrome (PCOS), with deleterious psychological effects warranting acknowledgment and a clear imperative to provide effective management. To our knowledge, this is the first review to exclusively examine the effectiveness of laser and light-based therapies in addressing hirsutism in women with PCOS.ObjectiveTo synthesize
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Weekly Pulsed Dye Laser Treatments for Port-Wine Birthmarks in Infants JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-17 Shirin Bajaj, Joy Tao, David A. Hashemi, Roy G. Geronemus
ImportanceEarly treatment of port-wine birthmark (PWB) can be life-altering and is often associated with improved outcomes and quality of life. There is growing evidence that shorter treatment intervals may play a role in more rapid PWB clearance; however, the optimal treatment interval has not been established.ObjectiveTo describe the outcomes of once-weekly pulsed dye laser (PDL) treatments for PWB
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Keratoacanthoma and Cutaneous Squamous Cell Carcinoma With PD-1 and PD-L1 Inhibitor Use. JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-10 Pushkar Aggarwal, Denise Clark, Aatman Shah, Kyle Rismiller, Scott A Neltner
This cross-sectional study assesses risk of dermatological immune-related adverse events associated with immunotherapy for cancer.
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Onychomycosis. JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-10 Adam I Rubin
This Patient Page describes the risk factors, clinical features, diagnosis, and treatment of onychomycosis.
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Oral Minoxidil vs Topical Minoxidil for Male Androgenetic Alopecia JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-10 Mariana Alvares Penha, Hélio Amante Miot, Michal Kasprzak, Paulo Müller Ramos
ImportanceThere has been increased interest in low-dose oral minoxidil for androgenetic alopecia (AGA) treatment. However, the efficacy of oral minoxidil for male AGA is yet to be evaluated in comparative therapeutic trials.ObjectiveTo compare the efficacy, safety, and tolerability of daily oral minoxidil, 5 mg, vs twice-daily topical minoxidil, 5%, for 24 weeks in the treatment of male AGA.Design
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Guselkumab for Pityriasis Rubra Pilaris and Dysregulation of IL-23/IL-17 and NFkB Signaling JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-10 Rose C. Velasco, Connie Shao, Brett Cutler, Jennifer Strunck, Gail Kent, Pamela B. Cassidy, Keith Choate, Teri M. Greiling
ImportanceThere is no US Food and Drug Administration–approved treatment for pityriasis rubra pilaris (PRP), and it is common for patients to fail to experience improvement with several systemic options. Involvement of interleukin (IL) 23 suggests a potential therapeutic target.ObjectiveTo determine whether guselkumab, an IL-23p19 inhibitor, provides clinical improvement for participants with PRP and
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Assessing Time of Onset for Interstitial Lung Disease in Anti-MDA5 Antibody-Positive Dermatomyositis JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-10 Rachel R. Lin, Peyton V. Warp, Andrea D. Maderal, Scott A. Elman
This cohort study seeks to describe the time interval between interstitial lung disease and anti–melanoma differentiation-associated gene 5 antibody-positive dermatomyositis diagnoses.
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Chronic Mucocutaneous Candidiasis Due to STAT1 Gene Variant JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-10 Danrui Jing, Guanzhao Liang, Xiaofang Li
This case report describes a man in his 40s who presented with a 5-month history of recurrent pruritic papular erythema with mild scaling on the face, left forearm, and groin.
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Tofacitinib Treatment for Pretibial Myxedema. JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-03 Su Wang, Xinyi Chen, Juan Bai, Qingmiao Sun, Hong Fang, Jianjun Qiao
This case report describes tofacitinib treatment for 2 patients with pretibial myxedema.
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Emergency Contraception for Patients Taking Isotretinoin. JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-03 Sarah Gold, Sarah Horvath, Andrea Zaenglein
This Viewpoint explains the need for emergency contraception as the last chance to avoid pregnancy for patients taking isotretinoin.
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Cutaneous Stigmata of Bacterial Endocarditis. JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-03 Matteo Castrichini, Robert J Haemmerle, Pritish K Tosh
This case report describes Osler nodes and Janeway lesions on a man in his 70s.
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Barriers and Facilitators Affecting Long-Term Antibiotic Prescriptions for Acne Treatment JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-03 Ronnie A. Festok, Avni S. Ahuja, Jared Y. Chen, Lena Chu, Jason Barron, Katherine Case, Elaine Thompson, Suephy C. Chen, Jonathan Weiss, Robert A. Swerlick, Cam Escoffery, Howa Yeung
ImportanceDermatologists prescribe more oral antibiotics per clinician than clinicians in any other specialty. Despite clinical guidelines that recommend limitation of long-term oral antibiotic treatments for acne to less than 3 months, there is little evidence to guide the design and implementation of an antibiotic stewardship program in clinical practice.ObjectiveTo identify salient barriers and
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Red Nodule on the Scalp in a Healthy Young Man JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-03 Constanza del Puerto, Soledad Aspillaga, Alex Castro
A man in his 40s was referred for an 8-mm red, firm, mobile nodule with irregular red lacunae and vessels and an absence of septa. What is your diagnosis?
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Human Leukocyte Antigens and Sulfamethoxazole/Cotrimoxazole–Induced Severe Cutaneous Adverse Reactions JAMA Dermatol. (IF 10.9) Pub Date : 2024-04-03 Po-Chien Wu, Wei-Ti Chen, I-Hsin Huang, Chun-Bing Chen, Chuang-Wei Wang, Cheng-Chen Tai, Wen-Hung Chung, Ching-Chi Chi
ImportanceSulfamethoxazole (SMX) and cotrimoxazole (CTX), a fixed-dose combination of SMX and trimethoprim in a 5:1 ratio, are antibacterial sulfonamides commonly used for treating various diseases. A substantial prevalence of severe cutaneous adverse reactions (SCARs) following the administration of these drugs has been reported. However, the association between human leukocyte antigen (HLA) genotypes
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Hyperhidrosis and Hypermobility Spectrum Disorders Among Adolescents. JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-27 Yair Zloof, Estela Derazne, Maya Braun, Rivka Friedland, Oded Scheuerman, Amir Shlaifer, Lotem Goldberg
This cross-sectional study assesses the prevalence and risk of excessive sweating and joint hypermobility in Israeli adolescents aged 16 to 19 years.
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Radiation Recall Dermatitis With Bruton Tyrosine Kinase Inhibitor Therapy JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-27 Ahmad Rajeh, Sarah Ferree, Milan J. Anadkat
This case report describes a woman in her 70s with a history of breast cancer and chronic lymphocytic leukemia who presented with a painful rash of the bilateral chest extending onto the flanks.
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Validation of Thermal Imaging and the ALT-70 Prediction Model to Differentiate Cellulitis From Pseudocellulitis JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-27 Michael S. Pulia, Rebecca J. Schwei, Roxana Alexandridis, Michael R. Lasarev, Edward Harwick, Robert Glinert, Ambar Haleem, Jamie Hess, Thomas D. Keenan, Joseph A. McBride, Robert Redwood
ImportanceCellulitis is misdiagnosed in up to 30% of cases due to mimic conditions termed pseudocellulitis. The resulting overuse of antibiotics is a threat to patient safety and public health. Surface thermal imaging and the ALT-70 (asymmetry, leukocytosis, tachycardia, and age ≥70 years) prediction model have been proposed as tools to help differentiate cellulitis from pseudocellulitis.ObjectivesTo
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Persistent Cutaneous Lesions of Darier Disease and Second-Hit Somatic Variants in ATP2A2 Gene JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-27 Lihi Atzmony, Fadia Zagairy, Banan Mawassi, Majd Shehade, Yasmin Tatour, Nada Danial-Farran, Morad Khayat, Nassim Warrour, Roni Dodiuk-Gad, Eran Cohen-Barak
ImportanceDarier disease (DD) is a rare genetic skin disorder caused by heterozygous variants in the ATP2A2 gene. Clinical manifestations include recurrent hyperkeratotic papules and plaques that occur mainly in seborrheic areas. Although some of the lesions wax and wane in response to environmental factors, others are severe and respond poorly to therapy.ObjectiveTo investigate the molecular mechanism
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Pigmentary Changes in a Woman With Oral Lichen Planus JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-20 Hani Hammoud, Salih Mishlab, Emily Avitan-Hersh
A woman in her 60s presented with oral lichen planus on hands and cheeks since childhood and also present in her parent and sibling. What is your diagnosis?
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Orofacial Anomalies in Kindler Epidermolysis Bullosa JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-20 Susanne Krämer, Anna Lena Hillebrecht, Yao Wang, Mihail-Alexandru Badea, Jose Ignacio Barrios, Sorina Danescu, Ignacia Fuentes, Demet Kartal, Alfred Klausegger, Enrique Ponce de León, Reinhard Schilke, Ivelina Yordanova, Agnes Bloch-Zupan, Cristina Has
ImportanceKindler epidermolysis bullosa is a genetic skin-blistering disease associated with recessive inherited pathogenic variants in FERMT1, which encodes kindlin-1. Severe orofacial manifestations of Kindler epidermolysis bullosa, including early oral squamous cell carcinoma, have been reported.ObjectiveTo determine whether hypoplastic pitted amelogenesis imperfecta is a feature of Kindler epidermolysis
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Outcome Measurement Instruments Used to Evaluate Dermatologic Adverse Events in Cancer Trials JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-20 Sheila Shaigany, Nicole Mastacouris, Rachel Tannenbaum, Andrew Strunk, Christopher Luan, Joshua Burshtein, Aaron Burshtein, Richard Carvajal, Amit Garg, Allireza Alloo
ImportanceAssessment of type, severity, and impact of dermatologic adverse events (DAEs) necessitates well-developed and validated clinician-reported outcome measures (ClinROMs) and patient-reported outcome measures (PROMs) that evaluate concepts specific to mucocutaneous toxic effects and that allow appropriate interpretation and comparison of DAEs across trials.ObjectiveTo evaluate heterogeneity
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Prevalence and Patient Characteristics of Ectodermal Dysplasias in Denmark JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-13 Laura Krogh Herlin, Sigrun A. J. Schmidt, Xenia Buus Hermann, Kirsten Rønholt, Anette Bygum, Annette Schuster, Ulrikke Lei, Mette Mogensen, Gabrielle R. Vinding, Malene Djursby, Hanne Hove, Jenny Blechingberg, Lise Graversen, Trine H. Mogensen, Hans Gjørup, Sinéad M. Langan, Mette Sommerlund
ImportanceEctodermal dysplasias constitute a group of rare genetic disorders of the skin and skin appendages with hypodontia, hypotrichosis, and hypohidrosis as cardinal features. There is a lack of population-based research into the epidemiology of ectodermal dysplasias.ObjectiveTo establish a validated population-based cohort of patients with ectodermal dysplasia in Denmark and to assess the disease
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Mal de Meleda JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-13 Pei-Yun Ho, Yi-Tsz Lin
This case report describes diffuse waxy palmoplantar hyperkeratosis in a symmetrically well-demarcated “gloves and socks” distribution with nail dystrophy.
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Consent and Identifiability for Patient Images in Research, Education, and Image-Based Artificial Intelligence JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-13 Trina Salvador, Lilly Gu, Jennifer L. Hay, Nicholas R. Kurtansky, Ruth Masterson-Creber, Allan C. Halpern, Veronica Rotemberg
This survey study reports the perspectives and preferences of US adults regarding use of photographs of their skin in medical research, education, and development of image-based artificial intelligence (AI).
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Expert Recommendations on Use of Topical Therapeutics for Vitiligo in Pediatric, Adolescent, and Young Adult Patients JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-13 Yael Renert-Yuval, Khaled Ezzedine, Pearl Grimes, David Rosmarin, Lawrence F. Eichenfield, Leslie Castelo-Soccio, Victor Huang, Seemal R. Desai, Samantha Walsh, Jonathan I. Silverberg, Amy S. Paller, Michele Rodrigues, Mark Weingarten, Shanthi Narla, Jackie Gardner, Michael Siegel, Sidra Ibad, Nanette B. Silverberg
ImportanceEvidence-based recommendations for the treatment of vitiligo in pediatric, adolescent, and young adult patients in the US are needed.ObjectiveTo develop evidence- and consensus-based expert recommendations on the diagnosis and treatment of vitiligo in young patients.Evidence ReviewA process was developed to produce consensus recommendations addressing questions regarding pediatric vitiligo
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Adjuvant Immunotherapy in Stage II Melanoma—Further Risk Stratification is Needed JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-13 Hannah Rashdan, Adewole Adamson, Yevgeniy R. Semenov
This Viewpoint reviews the evidence for immune checkpoint inhibitor use in the adjuvant setting, discusses the individual and societal risks, benefits, and costs associated with immune checkpoint inhibitors, and highlights the need for more targeted patient selection approaches.
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Current State of Dermatology Mobile Applications With Artificial Intelligence Features JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-07 Shannon Wongvibulsin, Matthew J. Yan, Vartan Pahalyants, William Murphy, Roxana Daneshjou, Veronica Rotemberg
ImportanceWith advancements in mobile technology and artificial intelligence (AI) methods, there has been a substantial surge in the availability of direct-to-consumer mobile applications (apps) claiming to aid in the assessment and management of diverse skin conditions. Despite widespread patient downloads, these apps exhibit limited evidence supporting their efficacy.ObjectiveTo identify and characterize
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Symptoms of Cognitive Impairment Among Children With Atopic Dermatitis JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-06 Emily Z. Ma, Hannah R. Chang, Sarah Radtke, Joy Wan
ImportancePrevious studies suggest that atopic dermatitis (AD) is associated with cognitive impairment in children, but these studies have relied primarily on neurodevelopmental diagnoses (rather than symptoms) as proxy measures of cognitive function. It remains unknown if certain subpopulations of children with AD are at greater risk of cognitive impairment.ObjectiveTo examine the association of AD
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Erythematous Plaque Studded With Papules and Pustules in an Immunocompetent Patient JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-06 Ahmad B. Shahin, Munir H. Idriss, Julia S. Lehman
A male patient was evaluated by the dermatology inpatient consult service after a 5-week history of a skin lesion on the right anterior thigh with intermittent itching and mild tenderness to palpation. What is your diagnosis?
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Anatomic Subtype Differences in Extramammary Paget Disease JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-06 Nour Kibbi, Joshua L. Owen, Brandon Worley, Jake X. Wang, Vishnu Harikumar, Sumaira Z. Aasi, Sunandana Chandra, Jennifer N. Choi, Yasuhiro Fujisawa, Christos Iavazzo, John Y. S. Kim, Naomi Lawrence, Mario M. Leitao, Allan B. MacLean, Jeffrey S. Ross, Anthony M. Rossi, Sabah Servaes, Michael J. Solomon, Murad Alam
ImportanceExtramammary Paget disease (EMPD) is a rare, highly recurrent cutaneous malignant neoplasm of unclear origin. EMPD arises most commonly on the vulvar and penoscrotal skin. It is not presently known how anatomic subtype of EMPD affects disease presentation and management.ObjectiveTo compare demographic and tumor characteristics and treatment approaches for different EMPD subtypes. Recommendations
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Immunohistochemistry for Diagnosing Melanoma in Older Adults JAMA Dermatol. (IF 10.9) Pub Date : 2024-03-06 Kenechukwu Ojukwu, Megan M. Eguchi, Adewole S. Adamson, Kathleen F. Kerr, Michael W. Piepkorn, Stacey Murdoch, Raymond L. Barnhill, David E. Elder, Stevan R. Knezevich, Joann G. Elmore
ImportancePathologic assessment to diagnose skin biopsies, especially for cutaneous melanoma, can be challenging, and immunohistochemistry (IHC) staining has the potential to aid decision-making. Currently, the temporal trends regarding the use of IHC for the examination of skin biopsies on a national level have not been described.ObjectiveTo illustrate trends in the use of IHC for the examination
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Spesolimab Response in a Girl With Acrodermatitis Continua of Hallopeau. JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-28 Youcong Wang, Li Zhang, Jie Zheng, Xia Li, Lihong Chen
This case report summarizes the treatment of acrodermatitis continua of Hallopeau with spesolimab in a 9-year-old girl.
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Incidence and Factors Associated With Second Primary Invasive Melanoma in Norway JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-28 Reza Ghiasvand, Adele C. Green, Marit B. Veierød, Trude E. Robsahm
ImportancePatients diagnosed with a primary melanoma are at high risk of subsequent melanomas. Understanding the risk of second primary invasive melanoma and associated factors is crucial to optimize patient follow-up.ObjectiveTo assess the incidence rate of second primary invasive melanoma and time between the first and second primary invasive melanoma in the Norwegian population.Design, Setting,
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Patient-Reported Outcomes and Mortality in Cutaneous Chronic Graft-vs-Host Disease JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-28 Emily Baumrin, Daniel B. Shin, Nandita Mitra, Joseph Pidala, Najla El Jurdi, Stephanie J. Lee, Alison W. Loren, Joel M. Gelfand
ImportanceChronic graft-vs-host disease (GVHD) is associated with impaired quality of life and symptom burden. The independent association of skin involvement with patient-reported outcomes (PROs) and their utility as a clinical prognostic marker remain unknown. Identification of patients with cutaneous chronic GVHD and impaired PROs could assist in initial risk stratification and treatment selection
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Identifying Core Outcome Domains in Chronic Skin Disease Using the Best-Worst Scaling Method JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-21 Ali Shields, Frances K. Barg, Wendy Smith Begolka, Kathy Sage, Kelly Druby, George C. Gondo, David J. Margolis, Andrea L. Pusic, John S. Barbieri
ImportanceThe use of patient-reported outcome measures (PROMs) potentially holds promise as an opportunity to improve outcomes and quality of care for patients with skin disease, but the routine use of PROMs remains limited. While the Patient-Reported Outcomes Measurement Information System (PROMIS) has several strengths and domains relevant to those with chronic skin disease, it is not clear which
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Annular Erythematous Eruption in a Pediatric Patient. JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-21 Samar Sheriff, Soon Bahrami, Courtney R Schadt
An 11-year-old girl presented in autumn with an asymptomatic rash on her arms, face, and legs of a 3-week duration. What is your diagnosis?
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Use of Efficiency Frontiers to Align Prices and Clinical Benefits of Biologic Therapies for Plaque Psoriasis JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-21 Alexander C. Egilman, Aaron S. Kesselheim, Jerry Avorn, Adam J. N. Raymakers, Benjamin N. Rome
ImportanceThe US lacks a systematic approach for aligning drug prices with clinical benefit, and traditional cost-effectiveness analysis (CEA) faces political obstacles. The efficiency frontier (EF) method offers policymakers an alternative approach.ObjectiveTo assess how the EF approach could align prices and clinical benefits of biologic medications for plaque psoriasis and estimate price reductions
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Macrocheilia as an Atypical Clinical Presentation of Capillary Malformation–Arteriovenous Malformation Type 2 JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-14 Roger Rovira-López, Luis A. Pérez-Jurado, Ramon M. Pujol
This case report describes a 53-year-old man with multiple erythematous macules and papules diffusely distributed on the frontal area, cheeks, eyelids, nose, and supralabial skin.
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Deep Vein Thrombosis and Healing Outcomes in Patients With Pyoderma Gangrenosum JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-14 Hannah Zhao, Sidharth K. Sengupta, Jonathan M. Sisley, Olivia Haddadin, Hailey Pfeifer, Alex G. Ortega-Loayza
This single-center prospective case-control study assessed the association between deep vein thrombosis and healing outcomes in patients with pyoderma gangrenosum.
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Lived Experiences and Fear of Cancer Recurrence Among Survivors of Localized Cutaneous Melanoma JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-14 Ayisha N. Mahama, Courtney N. Haller, Jocelyn Labrada, Christie I. Idiong, Alex B. Haynes, Elizabeth A. Jacobs, Joel Tsevat, Michael P. Pignone, Adewole S. Adamson
ImportanceMost of the rapid increase in cutaneous melanoma incidence in the US has been localized disease that is treated surgically and is associated with high survival rates. However, little is known about the psychological well-being of survivors in the US.ObjectiveTo explore the lived experiences and fear of cancer recurrence among survivors of localized cutaneous melanoma.Design, Setting, and
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Efficacy and Durability of Intravenous Ertapenem Therapy for Recalcitrant Hidradenitis Suppurativa JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-14 Avigdor Nosrati, Peter Y. Ch’en, McCall E. Torpey, Neda Shokrian, Gretchen Ball, Gabrielle Benesh, Tyler M. Andriano, Tian Ran Zhu, Haley D. Heibel, H. Dean Hosgood, Kristina L. Campton, Steven R. Cohen
ImportanceHidradenitis suppurativa (HS) is a debilitating follicular skin disorder in which bacterial colonization is typical. Oral antibiotic efficacy can be unreliable; however, selective intravenous antibiotics, specifically ertapenem, may provide favorable clinical outcomes.ObjectiveTo explore optimal course duration, efficacy, and patient satisfaction associated with intravenous ertapenem for
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Clinical, Histologic, and Transcriptomic Evaluation of Sequential Fat Grafting for Morphea JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-07 Juzi Liu, Jing Wang, Qian Zhang, Feng Lu, Junrong Cai
ImportanceMorphea is a rare disease of unknown etiology without satisfactory treatment for skin sclerosis and soft tissue atrophy.ObjectiveTo provide clinical, histologic, and transcriptome evidence of the antisclerotic and regenerative effects of sequential fat grafting with fresh fat and cryopreserved stromal vascular fraction gel (SVF gel) for morphea.Design, Setting, and ParticipantsThis single-center
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Persistent Hyperkeratotic Plaques on a Man's Genitogluteal Area. JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-07 Qian Zhang, Cheng-Cheng Liu, Jiu-Hong Li
A man in his 40s presented with a 10-year history of pruritic lesions on the scrotum and buttock. What is your diagnosis?
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The Alopecia Areata Severity and Morbidity Index (ASAMI) Study: Results From a Global Expert Consensus Exercise on Determinants of Alopecia Areata Severity. JAMA Dermatol. (IF 10.9) Pub Date : 2024-2-7 Anthony Moussa, Michaela Bennett, Dmitri Wall, Nekma Meah, Katherine York, Laita Bokhari, Leila Asfour, Huw Rees, Leonardo Spagnol Abraham, Daniel Asz-Sigall, Fitnat Buket Basmanav, Wilma Bergfeld, Regina C Betz, Bevin Bhoyrul, Ulrike Blume-Peytavi, Valerie Callender, Vijaya Chitreddy, Andrea Combalia, George Cotsarelis, Brittany Craiglow, Rachita Dhurat, Jeff Donovan, Andrei Doroshkevich, Samantha
Current measures of alopecia areata (AA) severity, such as the Severity of Alopecia Tool score, do not adequately capture overall disease impact.
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Federated Learning for Decentralized Artificial Intelligence in Melanoma Diagnostics JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-07 Sarah Haggenmüller, Max Schmitt, Eva Krieghoff-Henning, Achim Hekler, Roman C. Maron, Christoph Wies, Jochen S. Utikal, Friedegund Meier, Sarah Hobelsberger, Frank F. Gellrich, Mildred Sergon, Axel Hauschild, Lars E. French, Lucie Heinzerling, Justin G. Schlager, Kamran Ghoreschi, Max Schlaak, Franz J. Hilke, Gabriela Poch, Sören Korsing, Carola Berking, Markus V. Heppt, Michael Erdmann, Sebastian
ImportanceThe development of artificial intelligence (AI)–based melanoma classifiers typically calls for large, centralized datasets, requiring hospitals to give away their patient data, which raises serious privacy concerns. To address this concern, decentralized federated learning has been proposed, where classifier development is distributed across hospitals.ObjectiveTo investigate whether a more
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Support Group Participation Among Patients With Alopecia Areata. JAMA Dermatol. (IF 10.9) Pub Date : 2024-02-07 Reneé Haughton, Samantha Herbert, Summer Meyer, Olivia Kam, Emanual Maverakis, Maija Kiuru
This cross-sectional study describes support group use and experience among patients with alopecia areata.
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Estimated Spending on Beremagene Geperpavec for Dystrophic Epidermolysis Bullosa JAMA Dermatol. (IF 10.9) Pub Date : 2024-01-31 Adam J. N. Raymakers, Aaron S. Kesselheim, Arash Mostaghimi, William B. Feldman
ImportanceNew gene therapies can offer substantial benefits to patients, particularly those with rare diseases who have few therapeutic options. In May 2023, the US Food and Drug Administration (FDA) approved the first topical gene therapy, beremagene geperpavec (B-VEC), for treating both autosomal recessive and autosomal dominant dystrophic epidermolysis bullosa (DEB). However, FDA approval was based
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Short-Term Cardiovascular Complications in Dermatology Patients Receiving JAK-STAT Inhibitors JAMA Dermatol. (IF 10.9) Pub Date : 2024-01-31 Patrick A. Ireland, Nicholas Jansson, Sascha K. R. Spencer, Jorja Braden, Deshan Sebaratnam
ImportanceEvolving evidence suggests that patients receiving Janus kinase–signal transducer and activator of transcription inhibitors (JAK-STATi) may be at higher risk of major adverse cardiovascular events (MACE) and venous thromboembolism (VTE). Most existing literature has focused on indications that may confer a higher MACE and VTE risk than that among patients with isolated dermatological indications
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Prevalence of Pretreatment Testing Recommended for Patients With Chronic Inflammatory Skin Diseases JAMA Dermatol. (IF 10.9) Pub Date : 2024-01-31 Maria C. Schneeweiss, Denys Shay, Sophia Ly, Richard Wyss, Sebastian Schneeweiss, Robert J. Glynn, Arash Mostaghimi
ImportanceLaboratory testing for the presence of tuberculosis, hepatitis, and other conditions before starting most systemic immunomodulatory agents is recommended in patients with chronic inflammatory skin diseases (CISD) but current testing patterns in the US are unclear.ObjectiveTo determine the prevalence of pretreatment testing that is recommended for patients with CISD (psoriasis, hidradenitis
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Perspectives on Full-Body Skin Examinations Among Sexual and Gender Minority Patients JAMA Dermatol. (IF 10.9) Pub Date : 2024-01-31 Michelle Verghese, Jincong Q. Freeman, Brian W. Connor, Aniruddha Hazra, Andrew R. Fisher, Adena E. Rosenblatt
This survey study assesses full-body skin examination rates among sexual and gender minority patients and investigates their comfort with and reasons for discomfort during these examinations.
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Favre-Racouchot Syndrome JAMA Dermatol. (IF 10.9) Pub Date : 2024-01-31 Zhendong Wei, Fan Wang, Song Zheng
This case report describes multiple solitary open black comedones located bilaterally on the malar cheeks and temples as well as yellowish, smooth-surfaced papulonodular lesions in close association with the comedones.
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Retrospective Case Series of Cocaine-Associated Plasma Cell Orificial Mucositis JAMA Dermatol. (IF 10.9) Pub Date : 2024-01-24 Myriam Viedma-Martinez, Gonzalo Gallo-Pineda, Miguel Recio-Monescillo, David Jimenez-Gallo, Pablo Lopez-Sanz, Marta Drake-Monfort, Peru Urigoitia-Ugalde, Vicenta Martínez-Signes, David Llorca-Juan, Laura Fuertes-Vega, Elisa Ríos-Viñuela, Eduardo Escario-Travesedo, Juan José Ríos-Martín, Luis Requena-Caballero, Mario Linares-Barrios
ImportancePlasma cell orificial mucositis (PCOM) associated with cocaine use is an emerging, rare condition that has become a concern in Spain in recent years. Limited knowledge exists regarding this novel condition.ObjectivesTo delineate the clinicopathologic characteristics of this emerging entity and establish a novel approach in the differential diagnosis of cocaine-associated lesions.Design, Setting
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Annular Erythematous Plaques With Overlying Blisters in a Cluster of Jewels Pattern JAMA Dermatol. (IF 10.9) Pub Date : 2024-01-24 Pablo López Sanz, Carlota Rodríguez de Vera Guardiola, Eduardo Escario Travesedo
A woman in her 80s presented with erythematous, nondesquamative, annular plaques in a cluster of jewels pattern on her wrists and legs. What is your diagnosis?
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Patient-Reported Outcome Measures for Health-Related Quality of Life in Patients With Psoriasis JAMA Dermatol. (IF 10.9) Pub Date : 2024-01-24 Lourdes M. Pérez-Chada, Zachary H. Hopkins, Deepak M. W. Balak, Sarem Rashid, Andrew Creadore, Brian Chu, Camila Villa, Michael J. Woodbury, April W. Armstrong, Vibeke Strand, Alice B. Gottlieb, Joseph F. Merola, John S. Barbieri
ImportanceMultiple patient-reported outcome measures (PROMs) for health-related quality of life (HRQL) exist for patients with psoriasis. Evidence for the content validity and other measurement properties of these PROMs is critical to determine which HRQL PROMs could be recommended for use.ObjectiveTo systematically review the validity of HRQL-focused PROMs used in patients with psoriasis.Evidence
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Clinical Features and Outcomes of Black Patients with Melanoma JAMA Dermatol. (IF 10.9) Pub Date : 2024-01-24 Sophia N. Wix, Ariel B. Brown, Meghan Heberton, Adewole S. Adamson, Jennifer G. Gill
ImportanceMelanoma in Black individuals has an annual incidence of approximately 1 in 100 000 people. Most studies of melanoma in Black patients have used population databases, which lack important, precise clinical details.ObjectiveTo identify patient-level and tumor-level characteristics of melanoma in Black patients.Design, Setting, and ParticipantsThis case series included Black patients with melanoma
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Alopecia Areata. JAMA Dermatol. (IF 10.9) Pub Date : 2024-01-24 Ahana Gaurav, Brynner Eang, Arash Mostaghimi
This Patient Page describes the symptoms, diagnosis, and treatment of alopecia areata.