A 62 year old man presented with a one year history of asymptomatic hyperpigmentation of the flexural and intertriginous areas, especially in the groin (fig 1). He had thickened skin on his palms, feet, and neck, had lost 15 kg in three years, and had experienced nail dystrophy (melanonychia and onychoatrophy) for two years. He had recently received a diagnosis of unexplained hypothyroidism and hypogonadism. What is the most likely diagnosis?
Hyperpigmented, velvety skin lesions in the groin
Acanthosis …

中文翻译：

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皮肤皱纹过度色素沉着

一名62岁的男性表现出一年的弯曲和三端区无症状性色素沉着病史，尤其是在腹股沟处（图1）。他的手掌，脚和脖子上的皮肤增厚，三年内体重减轻了15公斤，并且经历了两年的指甲营养不良（黑色金属甲和甲癣）。他最近接受了无法解释的甲状腺功能减退和性腺机能减退的诊断。什么是最可能的诊断？
腹股沟
棘皮症的色素沉着，天鹅绒般的皮肤病变……