Survivors of Hodgkin lymphoma (HL) have a high risk of developing a subsequent breast cancer, particularly after chest irradiation.^1,2 Although breast cancer is a heterogeneous disease, the association between HL treatment and the estrogen receptor (ER) status of subsequent breast cancers has not been examined in large cohorts. We explored the association between radiotherapy for HL and risk of ER-positive and ER-negative breast cancer in a large, population-based cohort, accounting for chemotherapy.

中文翻译：

---

霍奇金淋巴瘤的治疗与随后乳腺癌的雌激素受体状态的关联

霍奇金淋巴瘤（HL）的幸存者患上随后的乳腺癌的风险很高，尤其是在胸部照射后。^{[ 1,2]}尽管乳腺癌是一种异质性疾病，但在大型队列研究中尚未检查HL治疗与后续乳腺癌的雌激素受体（ER）状态之间的关联。我们在一个以人群为基础的队列研究中探讨了HL放疗与ER阳性和ER阴性乳腺癌风险之间的关联，并考虑了化学治疗。