Chiral induction was utilized for the synthesis of diastereopure cyclic peptoids containing an N-benzyl alanine residue. Molecular modeling, NMR spectroscopy, single-crystal X-ray diffraction studies, and HPLC with chiral stationary phase demonstrated easy formation of free and sodium/benzylammonium complexed cyclic oligomers through strategic incorporation of a single stereogenic center in the oligomeric backbone. The synthesis of cyclic peptoids with defined conformational chirality and appropriate side chain topology is now possible.

中文翻译：

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环状拟肽作为拓扑模板：通过中心到构象手性诱导合成。

手性诱导用于合成含有N-苄基丙氨酸残基的非对映体环状拟肽。分子建模，NMR光谱学，单晶X射线衍射研究和具有手性固定相的HPLC表明，通过在寡聚主链中策略性地并入单个立体生成中心，可以轻松形成游离的钠盐和苄基铵络合的环状低聚物。现在可以合成具有确定的构象手性和合适的侧链拓扑的环状类肽。