Tests sensitive to presymptomatic changes in Alzheimer's disease could be valuable for clinical trials. Accelerated long-term forgetting-during which memory impairment becomes apparent over longer periods than usually assessed, despite normal performance on standard cognitive testing-has been identified in other temporal lobe disorders. We assessed whether accelerated long-term forgetting is a feature of presymptomatic autosomal dominant (familial) Alzheimer's disease, and whether there is an association between accelerated long-term forgetting and early subjective memory changes.

中文翻译：

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症状前常染色体显性遗传阿尔茨海默氏病的长期遗忘加速：一项横断面研究。

对阿尔茨海默氏病症状发生前变化敏感的检测对于临床试验可能是有价值的。尽管在标准认知测试中表现正常，但在其他颞叶疾病中也发现了加速的长期遗忘，在此期间记忆障碍的发作时间比通常评估的更长。我们评估了加速的长期遗忘是否是症状前常染色体显性（家族性）阿尔茨海默氏病的特征，以及加速的长期遗忘与早期主观记忆变化之间是否存在关联。