Food restriction (FR) is the most commonly used intervention to prevent the overweight. However, the lost weight is usually followed by "compensatory growth" when FR ends, resulting in overweight. The present study was aimed to examining the behavior patterns and hormones mechanisms underpinning the over-weight. Energy budget and body fat content, and several endocrine markers related to leptin signals were examined in the striped hamsters under 20% FR refed by either low-fat diet (LF group) or high-fat diet (HF group). Body mass and fat content significantly regained when FR ended, and the hamsters in HF group showed 49.1% more body fat than in LF group (P < 0.01). Digestive energy intake was higher by 20.1% in HF than LF group, while metabolic thermogenesis and behavior patterns did not differed between the two groups. Gene expression of leptin receptor and anorexigenic peptides of pro-opiomelanocortin and cocaine- and amphetamine-regulated transcript in hypothalamus were significantly up-regulated in LF group, but down-regulated in HF group. It suggests that effective leptin signals to the brain were involved in attenuation of hyperphagia in hamsters refed with LF. However, "leptin resistance" probably occurred in hamsters refed with HF, which impaired the control of hyperphagia, resulting in development of over-weight.

中文翻译：

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瘦素抵抗力与高脂饮食喂养的条纹仓鼠对超重的敏感性有关。

食物限制（FR）是防止超重的最常用干预手段。但是，减肥通常在FR结束后进行“补偿性生长”，从而导致超重。本研究旨在检查超重的行为模式和激素机制。在低脂饮食（LF组）或高脂饮食（HF组）确定的20％FR以下的条纹仓鼠中，检查了能量收支和体内脂肪含量以及与瘦素信号相关的几种内分泌标记物。FR结束后体重和脂肪含量显着恢复，HF组的仓鼠体内脂肪比LF组增加49.1％（P <0.01）。HF组的消化能摄入量比LF组高20.1％，而两组之间的代谢产热和行为模式无差异。LF组下丘脑中瘦素受体的基因表达，促视神经黑皮质素的促厌食肽，可卡因和苯丙胺调节的转录本均显着上调，而在HF组则显着下调。这表明，向大脑发送的有效瘦素信号与LF所致仓鼠的吞噬过度有关。但是，“瘦素抵抗”可能发生在用HF喂养的仓鼠中，这削弱了对食欲亢进的控制，导致体重增加。这表明，向大脑发送的有效瘦素信号与LF所致仓鼠的吞噬过度有关。但是，“瘦素抵抗”可能发生在用HF喂养的仓鼠中，这削弱了对食欲亢进的控制，导致体重增加。这表明，向大脑发送的有效瘦素信号与LF所致仓鼠的吞咽过多有关。但是，“瘦素抵抗”可能发生在用HF喂养的仓鼠中，这削弱了对食欲亢进的控制，导致体重增加。