Alcohol addiction is accompanied by aberrant neural activity. Previously, task-based fMRI and resting-state EEG studies have revealed that craving, a critical component of addiction, is linked to abnormal activity in cortical regions including the dorsal anterior cingulate cortex (dACC), nucleus accumbens (NAcc), posterior cingulate cortex (PCC) and pregenual anterior cingulate cortex (pgACC), etc. In this study, we combine these two imaging techniques to investigate a group of alcohol-addicted patients and provide convergent evidence for the neural correlates of craving not only in alcohol but substance abuse in general. We observe abnormal BOLD signal levels in the dACC, NAcc, pgACC, PCC, amygdala, and parahippocampus (PHC) in a cue-reactivity fMRI experiment. These findings are consistent with increased beta-band activity in the dACC and pgACC in resting-state EEG. We further observe desynchronization characterized by decreased functional connectivity in cue-based fMRI and hypersynchronization characterized by increased functional connectivity between these regions in the theta frequency band. The results of our study show a consistent pattern of alcohol craving elicited by external cues and internal desires. Given the advantage of superior spatial and temporal resolution, we hypothesize a "central craving network" that integrates the different aspects of alcohol addiction into a unified percept.

中文翻译：

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与酒精相关的渴望的统一感知的神经关联：功能磁共振成像和脑电图研究。

酒精成瘾伴随着异常的神经活动。此前，基于任务的功能磁共振成像和静息态脑电图研究表明，成瘾的关键组成部分——渴望与背侧前扣带皮层（dACC）、伏隔核（NAcc）、后扣带皮层等皮质区域的异常活动有关。 （PCC）和前扣带皮层（pgACC）等。在本研究中，我们结合这两种成像技术来调查一组酒精成瘾患者，并为渴望酒精和药物滥用的神经相关性提供收敛证据一般来说。我们在提示反应性 fMRI 实验中观察到 dACC、NAcc、pgACC、PCC、杏仁核和海马旁回 (PHC) 中异常的 BOLD 信号水平。这些发现与静息状态 EEG 中 dACC 和 pgACC 的 β 带活动增加一致。我们进一步观察到去同步化的特征是基于线索的功能磁共振成像中功能连接性的降低，而超同步化的特征是θ频带中这些区域之间功能连接性的增加。我们的研究结果表明，外部暗示和内部欲望引发的酒精渴望具有一致的模式。鉴于优越的空间和时间分辨率的优势，我们假设有一个“中央渴望网络”，它将酒精成瘾的不同方面整合成一个统一的感知。