Photolabile caged versions of 9‐aminodoxycycline that photolyse after visible light irradiation or 740 nm two‐photon excitation are reported. 9‐Aminodoxycycline is a tetracycline analogue that can be efficiently coupled to photoremovable protecting groups by carbamoylation, leading to new caged doxycycline derivatives that can be used in combination with the TetOn system for photoactivated gene expression.

中文翻译：

---

具有两个光子敏感的可光去除基团的光激活性强力霉素类似物的合成和表征，适用于光诱导的基因表达

据报道，在可见光辐照或740 nm双光子激发后，光解笼罩的9-氨基多西环素会发生光解。9‐Aminodoxycycline是一种四环素类似物，可通过氨基甲酰化作用与光可去除保护基团有效偶联，从而产生可与TetOn系统结合使用的新笼状强力霉素衍生物，以进行光激活基因表达。