A palladium-catalyzed four-component cascade reaction of carbon dioxide, amines, allenyl ethers, and aryl iodides has been developed for the first time. The novel reaction allows simultaneous construction of three different new bonds (C–N, C–O, and C–C) in a single step, affording an efficient method for the synthesis of a variety of highly functionalized acyclic O,O-acetals. Excellent chemo- and regioselectivity, wide substrate scope, and good functional group tolerance are features of the method.

中文翻译：

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钯催化四组分级联反应合成高官能度无环O，O-缩醛

首次开发了钯催化的二氧化碳，胺，烯丙基醚和芳基碘化物的四组分级联反应。这种新颖的反应可以在一个步骤中同时构建三个不同的新键（C–N，C–O和C–C），为合成各种高度官能化的无环O，O-缩醛提供了一种有效的方法。该方法具有出色的化学和区域选择性，广泛的底物范围以及良好的官能团耐受性。