Alum, the well‐known vaccine adjuvant with a long history of clinical use, is changed from a “gel” to nanoparticles. This changes its mechanism of action from a “depot” that resides at the injection site, to nanoparticles that transport antigen and adjuvant into the lymph node. As reported by Xun Sun and co‐workers in article number 1700426, this lymph node targeting strategy significantly improves the efficacy of vaccinations and offers a potential nanovaccine platform for treating cancer and other diseases.

中文翻译：

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疫苗递送：将旧的佐剂从凝胶变成纳米颗粒，以放大CD8 + T细胞反应（Adv。Sci。1/2018）

明矾，具有悠久的临床使用历史的著名疫苗佐剂，已从“凝胶”变为纳米颗粒。这将其作用机理从位于注射部位的“贮库”改变为将抗原和佐剂转运到淋巴结的纳米颗粒。正如Xun Sun及其同事在文章1700426中所报道的那样，这种靶向淋巴结的策略显着提高了疫苗接种的效率，并为治疗癌症和其他疾病提供了潜在的纳米疫苗平台。