There is evidence from in vitro experiments that dipeptidyl peptidase IV (DPP IV) might play role(s) in amyloid formation. However, nothing is known about the localization of the enzyme in brains of individuals with Alzheimer's disease. We herein show that in comparison to non-demented controls DPP IV is upregulated in AD brain neurons and occurs in multiple amyloid plaques.

中文翻译：

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可能在阿尔茨海默病（AD）病理中起重要作用的二肽基肽酶IV在AD脑神经元中上调并与淀粉样斑块相关

体外实验表明，二肽基肽酶IV（DPP IV）可能在淀粉样蛋白形成中起作用。但是，关于该酶在患有阿尔茨海默氏病的人的脑中的定位还一无所知。我们在本文中显示，与非痴呆对照相比，DPP IV在AD脑神经元中被上调并且发生在多个淀粉样斑块中。