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Effects of warfarin on biological processes other than haemostasis: A review
Food and Chemical Toxicology ( IF 4.3 ) Pub Date : 2018-01-17 , DOI: 10.1016/j.fct.2018.01.019
Aleksandra Popov Aleksandrov , Ivana Mirkov , Marina Ninkov , Dina Mileusnic , Jelena Demenesku , Vesna Subota , Dragan Kataranovski , Milena Kataranovski

Warfarin is the world's most widely used anticoagulant drug. Its anticoagulant activity is based on the inhibition of the vitamin K-dependent (VKD) step in the complete synthesis of a number of blood coagulation factors that are required for normal blood coagulation. Warfarin also affects synthesis of VKD proteins not related to haemostasis including those involved in bone growth and vascular calcification. Antithrombotic activity of warfarin is considered responsible for some aspects of its anti-tumour activity of warfarin. Some aspects of activities against tumours seem not to be related to haemostasis and included effects of warfarin on non-haemostatic VKD proteins as well as those not related to VKD proteins. Inflammatory/immunomodulatory effects of warfarin indicate much broader potential of action of this drug both in physiological and pathological processes. This review provides an overview of the published data dealing with the effects of warfarin on biological processes other than haemostasis.



中文翻译:

华法林对止血以外的生物过程的影响:综述

华法林是世界上使用最广泛的抗凝药物。它的抗凝血活性基于对正常凝血所需的多种凝血因子的完全合成中维生素K依赖性(VKD)步骤的抑制。华法林还影响与止血无关的VKD蛋白质的合成,包括与骨骼生长和血管钙化有关的蛋白质。华法林的抗血栓形成活性被认为是其华法林抗肿瘤活性的某些方面的原因。抗肿瘤活性的某些方面似乎与止血无关,包括华法林对非止血VKD蛋白质以及与VKD蛋白质无关的作用。华法林的炎症/免疫调节作用表明该药在生理和病理过程中具有更广泛的作用潜力。这篇综述概述了有关华法林对止血以外的生物过程影响的已发表数据。

更新日期:2018-01-17
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