Malaria remains one of the most deadly infectious diseases globally. Considering the growing spread of resistance, development of new and effective antimalarials remains an urgent priority. Quinolones, which are emerged as one of the most important class of antibiotics in the treatment of various bacterial infections, showed potential in vitro antiplasmodial and in vivo antimalarial activities, making them promising candidates for the chemoprophylaxis and treatment of malaria. This review presents the current progresses and applications of quinolone-based derivatives as potential antimalarials to pave the way for the development of new antimalarials.

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喹诺酮衍生物的抗血浆和抗疟疾活性：概述

疟疾仍然是全球最致命的传染病之一。考虑到抗药性的传播日益扩大，开发新的有效抗疟药仍然是当务之急。喹诺酮类药物已成为治疗各种细菌感染的最重要的抗生素之一，显示出潜在的体外抗血浆和体内抗疟活性，使其成为化学预防和治疗疟疾的有希望的候选者。这篇综述介绍了喹诺酮类衍生物作为潜在抗疟药的最新进展和应用，为新型抗疟药的开发铺平了道路。