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Annals for Hospitalists - 16 January 2018
Annals of Internal Medicine ( IF 39.2 ) Pub Date : 2018-01-16 , DOI: 10.7326/afho201801160
David H. Wesorick 1 , Vineet Chopra 1
Affiliation  

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Inpatient Notes

Modernizing Rounds—Why It's Time to Redesign Our Hospital Practice

—Jason Stein, MD, and Susan Shapiro, PhD, RN
How can we elevate the quality and efficiency of inpatient care? The authors of this month's Inpatient Notes explain why it is time for radical, disruptive change in how we organize our patients, and how we round on them.

Highlights of Recent Articles From Annals of Internal Medicine

Diagnosis of Venous Thromboembolism: 20 Years of Progress

Ann Intern Med. 2018;168:131-140. Published 9 January 2018. doi:10.7326/M17-0291
This article analyzed 29 systematic reviews/meta-analyses, 7 randomized controlled trials, and 22 prospective studies related to the diagnosis of venous thromboembolism and summarizes the optimal diagnostic approach.
Key points for hospitalists include:
  • The diagnosis of suspected pulmonary embolism (PE) is best approached by using an algorithm that includes the estimation of pretest probability, the selective use of D-dimer testing (in patients with low or moderate pretest probability), and the use of appropriate imaging tests (which can include lower-extremity compression ultrasonography, computed tomography (CT) pulmonary angiography, or ventilation–perfusion scanning). The authors provide a diagnostic algorithm incorporating these tests and strategies.

  • The use of pretest probability tools can help clinicians decide when imaging is necessary, but it can also be helpful in detecting false-positive imaging results. For example, the posttest probability of PE in a patient with low pretest probability and a positive CT pulmonary angiogram is only 30%. Positive scans in these patients should be reviewed with an imaging specialist.

  • Pretest probability tools have not been well-studied in hospitalized patients, and D-dimer testing is not useful in this population. Therefore, the authors recommend that the evaluation of hospitalized patients with suspected PE forgo the algorithmic approach and move directly to imaging.

Readmissions After Revascularization Procedures for Peripheral Arterial Disease: A Nationwide Cohort Study

Ann Intern Med. 2017;168:93-99. Published 5 December 2017. doi:10.7326/M17-1058
This retrospective cohort study examined data from 61 969 patients who were discharged after peripheral arterial revascularization. The 30-day nonelective readmission rate in this cohort was 17.6%.
Key points for hospitalists include:
  • Patients undergoing peripheral arterial revascularization have a very high 30-day readmission rate.

  • Although procedural complications account for the largest segment of these readmissions (28%), sepsis (8.3%), diabetes (7.5%), and congestive heart failure (4.4%) are also important causes of readmission.

  • Readmitted patients were more likely to have comorbid conditions, such as chronic limb ischemia, obesity, hypertension, congestive heart failure, diabetes, or renal disease.

The Latest Highlights From ACP Journal Club

Should patients with unprovoked venous thromboembolism (VTE) undergo extensive cancer screening?

Review: In patients with a first VTE, extended testing for undiagnosed cancer does not reduce mortality
Ann Intern Med. 2017;167:JC50. doi:10.7326/ACPJC-2017-167-12-064
This systematic review examined 4 randomized controlled trials (n = 1644) that compared standard testing with extensive testing (including CT of the abdomen and pelvis in 1 trial, and positron emission tomography scanning in another) in patients who presented with unprovoked VTE. Although more early cancer was discovered in the extensive testing group, no difference in cancer-related or all-cause mortality between groups was found after 2 years of follow-up. Despite the previously demonstrated relationship between VTE and cancer, these data do not support aggressive cancer screening in patients with unprovoked VTE.

Is triple antithrombotic therapy the optimal approach for patients with atrial fibrillation having percutaneous coronary intervention?

After PCI in AF, dual antithrombotic therapy with dabigatran reduced bleeding compared with triple therapy
Ann Intern Med. 2017;167:JC70. doi:10.7326/ACPJC-2017-167-12-070
In this randomized controlled trial (n = 2725), patients with atrial fibrillation having percutaneous coronary intervention were randomly assigned to receive triple therapy (aspirin, clopidogrel, and warfarin) or dual therapy with dabigatran (either 110 mg or 150 mg twice daily) and clopidogrel. There was no difference between groups in the rate of stent thrombosis or the composite outcome (myocardial infarction, stroke, systemic embolism, death, or unplanned revascularization). However, among patients receiving dual therapy, there was a statistically significant reduction in the risk for bleeding. Although the trial was not adequately powered to rule out a small difference in stent thrombosis between groups, it does add to mounting evidence that dual therapy may be safer than triple therapy in these patients.
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中文翻译:

医院医生纪事-2018年1月16日

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住院须知

现代化的诊疗室—为什么要重新设计我们的医院业务

—医学博士Jason Stein和RN博士Susan Shapiro
我们如何提高住院服务的质量和效率?本月《住院笔记》的作者解释了为什么现在该进行彻底的,颠覆性的变革了,我们如何组织患者以及如何对待患者。

《内科医学年鉴》近期文章摘要

静脉血栓栓塞的诊断:20年的进步

安实习生。2018; 168:131-140。发布于2018年1月9日。doi:10.7326 / M17-0291
本文分析了29项与静脉血栓栓塞诊断相关的系统评价/荟萃分析,7项随机对照试验和22项前瞻性研究,并总结了最佳的诊断方法。
住院医生的要点包括:
  • 诊断可疑肺栓塞(PE)的最佳方法是使用一种算法,包括估计预测概率,选择性使用D-二聚体检测(对于低或中等预检测概率的患者)以及使用适当的影像学检测(这可能包括下肢加压超声检查,计算机断层扫描(CT)肺血管造影或通气-灌注扫描)。作者提供了结合了这些测试和策略的诊断算法。

  • 使用预测概率工具可以帮助临床医生确定何时需要成像,但也有助于检测假阳性成像结果。例如,具有低前测概率和CT肺血管造影阳性的患者的PE的后测概率仅为30%。这些患者的阳性扫描应由影像学专家进行检查。

  • 住院患者对预测概率工具的研究还不够深入,D-二聚体测试在这一人群中没有用。因此,作者建议对住院的可疑PE患者进行评估应放弃算法方法,而应直接进行影像学检查。

周围动脉疾病血运重建手术后的再入院:全国队列研究

安实习生。2017; 168:93-99。2017年12月5日发布。doi:10.7326 / M17-1058
这项回顾性队列研究检查了61 969例在外周动脉血运重建后出院的患者的数据。该队列的30天非选择性入学率是17.6%。
住院医生的要点包括:
  • 进行外周动脉血运重建的患者有很高的30天再入院率。

  • 尽管手术并发症占这些再入院的最大部分(28%),败血症(8.3%),糖尿病(7.5%)和充血性心力衰竭(4.4%)也是再入院的重要原因。

  • 重新入院的患者更有可能患有合并症,例如慢性肢体缺血,肥胖,高血压,充血性心力衰竭,糖尿病或肾病。

ACP Journal Club的最新亮点

患有无缘无故的静脉血栓栓塞症(VTE)的患者是否应该进行广泛的癌症筛查?

回顾:对于初次接受VTE的患者,对未确诊的癌症进行扩展检测不能降低死亡率
安实习生。2017; 167:JC50。doi:10.7326 / ACPJC-2017-167-12-064
这项系统评价审查了4项随机对照试验(n = 1644),该试验将标准试验与广泛试验(包括1项试验的腹部和骨盆CT扫描,以及另一项正电子发射断层扫描)进行了比较,这些患者均表现为未经证实的VTE。尽管在广泛的测试组中发现了更多的早期癌症,但是在随访2年后,各组之间的癌症相关或全因死亡率没有差异。尽管先前已证明VTE与癌症之间存在相关性,但这些数据不支持未经证实的VTE患者进行积极的癌症筛查。

对于经皮冠状动脉介入治疗的房颤患者,三重抗栓治疗是否是最佳方法?

在房颤行PCI后,与三联疗法相比,达比加群双重抗栓治疗减少了出血
安实习生。2017; 167:JC70。doi:10.7326 / ACPJC-2017-167-12-070
在该随机对照试验(n = 2725)中,经皮冠状动脉介入治疗的房颤患者被随机分配接受三联疗法(阿司匹林,氯吡格雷和华法林)或达比加群双重疗法(每日两次,分别为110 mg或150 mg)和氯吡格雷。两组之间的支架血栓形成率或综合结局(心肌梗塞,中风,全身性栓塞,死亡或计划外血运重建)的发生率无差异。但是,在接受双重疗法的患者中,出血风险有统计学上的显着降低。尽管该试验不足以排除两组之间支架内血栓形成的微小差异,但确实增加了越来越多的证据表明,在这些患者中,双重治疗可能比三次治疗更为安全。
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更新日期:2018-01-16
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