Despite recent advances in analytical techniques, high-throughput and rapid screening of abused drugs and toxic compounds is imperative. In this study, a method hyphenating ion mobility spectrometry with high-resolution time-of-flight mass spectrometry (IM-TOF MS) was developed to measure commonly abused drugs and toxic compounds. IM spectrometry allows the measurement of the collision cross section (CCS) value while TOF MS provides the measurement of accurate mass. A total of 124 abused drugs and toxic compounds were evaluated. As a result, the experimental precision of the experimental CCS values was 0.25% or better and not affected by the processed matrices (∣ΔCCS∣_blood ≤ 0.77% and ∣ΔCCS∣_urine ≤ 0.93%). The experimental mass error was lower than 5 ppm. The screening limit of detection (LOD) was below 400 ng mL⁻¹ for 93% of the test compounds in urine and 90% in blood. Finally, the method was applied to real samples from a local forensic laboratory and methamphetamine was identified successfully. It was demonstrated that IM-TOF MS was a promising approach for rapid screening of abused compounds and would increase the detection throughout.

中文翻译：

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离子淌度衍生的碰撞截面是一项附加措施，可支持使用电喷雾离子淌度飞行时间质谱法对滥用药物和有毒化合物进行快速分析

尽管分析技术方面取得了最新进展，但仍必须对被滥用的药物和有毒化合物进行高通量和快速筛选。在这项研究中，开发了一种使用高分辨率飞行时间质谱（IM-TOF MS）联用离子迁移谱法的方法，以测量常见滥用的药物和有毒化合物。IM光谱仪可测量碰撞截面（CCS）值，而TOF MS可测量准确质量。总共对124种滥用药物和有毒化合物进行了评估。结果，实验CCS值的实验精度为0.25％或更高，并且不受处理基质的影响（∣ΔCCS∣_血液≤0.77％，andΔCCS∣_尿≤0.93％）。实验质量误差低于5 ppm。尿液中93％的受试化合物和血液中90％的检出限（LOD）低于400 ng mL ^-1。最后，将该方法应用于当地法医实验室的真实样品，并成功鉴定出甲基苯丙胺。事实证明，IM-TOF MS是一种快速筛选滥用化合物的有前途的方法，并且会增加整个检测范围。