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An electrochemical oxidative homo-coupling reaction of imidazopyridine heterocycles to biheteroaryls
Green Chemistry ( IF 9.8 ) Pub Date : 2018-01-16 00:00:00 , DOI: 10.1039/c7gc03563b
Yongyuan Gao 1, 2, 3, 4, 5 , Yang Wang 1, 2, 3, 4, 5 , Jie Zhou 6, 7, 8 , Haibo Mei 1, 2, 3, 4, 5 , Jianlin Han 1, 2, 3, 4, 5
Affiliation  

An electrochemical dehydrogenative homo-coupling reaction of imidazopyridine-based heterocycles has been developed, which affords biheteroaryls with good chemical yields and high regioselectivities. This reaction is conducted in a simple undivided cell at room temperature, which avoids the use of any metal-catalysts, additives and oxidants. This reaction tolerates a wide scope of substrates, which provides an easy and green strategy for the preparation of important bioactive biheteroaryl compounds.

中文翻译:

咪唑并吡啶杂环与双杂芳基的电化学氧化均偶联反应

已经开发了基于咪唑并吡啶的杂环的电化学脱氢均偶联反应,该反应提供了具有良好化学收率和高区域选择性的双杂芳基。该反应在室温下在简单的不分隔电池中进行,避免了使用任何金属催化剂,添加剂和氧化剂。该反应可耐受多种底物,为制备重要的生物活性双杂芳基化合物提供了简便而绿色的策略。
更新日期:2018-02-06
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