The Front Cover shows triplex‐forming ¹⁹F NMR probes that recognize nucleobase content in the pyrimidine‐rich strand of double‐helical DNA targets. The obtained ¹⁹F NMR resonances are sensitive to the base content, and unique ¹⁹F NMR‐spectral fingerprints could be obtained. The idea of the probes may find application in studies in which the goal is to simultaneously detect changes of local environments (e.g., upon binding of nucleobase‐specific ligands) in structurally resembling double‐helical stretches. More information can be found in the Full Paper by N. Bhuma, V. Tähtinen, and P. Virta.

中文翻译：

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封面：区分碱基的DNA-三链体形成19F NMR探针的合成和适用性（Eur.J.Org.Chem.5 / 2018）

前盖显示可形成三链体的¹⁹ F NMR探针，可识别双螺旋DNA靶标的富含嘧啶的链中的核碱基含量。获得的¹⁹ F NMR共振对碱基含量敏感，并且可以获得独特的¹⁹ F NMR光谱指纹。探针的想法可能会在研究中得到应用，这些研究的目的是在结构类似双螺旋拉伸中同时检测局部环境的变化（例如，结合碱基特异性配体）。可以在N. Bhuma，V。Tähtinen和P. Virta的论文全文中找到更多信息。