Peracetylated unnatural sugars the “arrows” used by glycoscientists for decades to label cellular glycans, can induce artificial cysteine glycosylation on various proteins, as reported in the Communication on page 1817 ff. by C. Wang, X. Chen et al. This “off-targeting” of the per-O-acetylated sugar reporters can be likened to Cao Cao shooting arrows at scarecrows and straw boats in the fictitious story “Romance of the Three Kingdoms”, and calls for caution in the use of peracetylated sugars and the development of better versions.

中文翻译：

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封底：在代谢型糖标记过程中，每O-乙酰化的非天然单糖诱导的人工半胱氨酸S-糖基化（Angew.Chem.Int.Ed.7 / 2018）

过乙酰化的非天然糖是糖科学家数十年来用来标记细胞聚糖的“箭头”，可以在各种蛋白质上诱导人工半胱氨酸糖基化，如《通讯》第1817页及其后各页所述。由C. Wang，X.Chen et al。可以说，这种“脱靶”的过氧乙酰化糖报道者可以比作曹操在虚构的故事《三个王国的浪漫》中用稻草人和稻草船射箭，并呼吁在使用过乙酰化糖时要谨慎以及开发更好的版本。