About ten years after their introduction to the market (happened in 2006), the so-called second generation superficially porous particles (SPPs) have undoubtedly become the benchmark as well as, very often, the preferred choice for many applications in liquid chromatography (LC), when high efficiency and fast separations are required. This trend has interested practically all kinds of separations, with the only exception of chiral chromatography (at least so far). The technology of production of base SPPs is advanced, relatively simple and widely available. The deep investigation of mass transfer mechanisms under reversed-phase (RP) and normal-phase (NP) conditions for achiral separations has shown the advantages in the use of these particles over their fully porous counterparts. In addition, it has been demonstrated that SPPs are extremely suitable for the preparation of efficient packed beds through slurry packing techniques. However, the research in this field is in continual evolution. In this article, some of the most advanced concepts and modern applications based on the use of SPPs, embracing in particular ultrafast chiral chromatography and the design of SPPs with engineered pore structures or very reduced particle diameter, are revised. We describe modern trends in these fields and focus on those aspect where further innovation and research will be required.

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所谓的第二代表面多孔颗粒（SPPs）投放市场大约十年（发生于2006年），无疑已成为基准，而且通常是液相色谱（LC）的许多应用的首选），需要高效率和快速分离。这种趋势几乎引起了所有分离的兴趣，只有手性色谱法例外（至少到目前为止）。基本SPP的生产技术是先进的，相对简单的并且可广泛使用。在反相（RP）和正相（NP）条件下进行非手性分离的传质机理的深入研究表明，与完全多孔的替代物相比，使用这些颗粒具有优势。此外，已经证明，SPP非常适合通过浆液填充技术制备有效的填充床。但是，该领域的研究仍在不断发展。在本文中，对基于SPP的使用的一些最先进的概念和现代应用进行了修改，特别是包括超快手性色谱法和具有工程孔结构或粒径非常减小的SPP的设计。我们描述了这些领域的现代趋势，并将重点放在需要进一步创新和研究的那些方面。尤其是涉及超快手性色谱法和具有工程化孔结构或非常减小的粒径的SPP的设计进行了修改。我们描述了这些领域的现代趋势，并将重点放在需要进一步创新和研究的那些方面。尤其是涉及超快手性色谱法和具有工程化孔结构或非常减小的粒径的SPP的设计进行了修改。我们描述了这些领域的现代趋势，并将重点放在需要进一步创新和研究的那些方面。

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