Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers.

中文翻译：

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HIV免疫原：亲和力是关键

广泛中和抗体的产生是HIV疫苗设计的主要目标，但前体B细胞很少见。雅培等。（2018）报告指出，需要高亲和力和亲和力的免疫原来促进生发中心低频B细胞的成熟。