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Synthesis of Optically Pure (S,E)-2-Amino-5-arylpent-4-enoic Acids by Heck Reactions of Nickel Complexes
Synlett ( IF 2 ) Pub Date : 2018-01-15 , DOI: 10.1055/s-0037-1609094
Peter Langer 1, 2 , Silvio Parpart 1 , Zorayr Mardiyan 1, 3, 4 , Peter Ehlers 1, 2 , Andranik Petrosyan 1, 2, 4 , Anna Mkrtchyan 3, 4 , Ashot Saghyan 3, 4
Affiliation  

Starting from commercially available building blocks a variety of enantiomerically pure (S)-2-amino-4-enoic acids has been synthesized by the Heck reaction using Ni-(S)-BPB {Nickel-N-[(S)-benzylprolyl]aminobenzophenone} as a chiral auxiliary. The reactions proceeded in very good yields and with high E-selectivity.

中文翻译:

通过镍配合物的 Heck 反应合成光学纯 (S,E)-2-Amino-5-arylpent-4-enoic酸

从可商购的结构单元开始,使用 Ni-(S)-BPB {Nickel-N-[(S)-benzylprolyl] 通过 Heck 反应合成了各种对映体纯 (S)-2-amino-4-enoic 酸氨基二苯甲酮}作为手性助剂。反应以非常好的产率和高 E 选择性进行。
更新日期:2018-01-15
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