Essential oil from Rosmarinus officinalis (Rosemary essential oil, EORO) may improve cognitive function by activating the central nervous system. However, no scientific basis for the effect of EORO has been described. Therefore, we investigated the effect of EORO on Alzheimer's type dementia using model mice. Mice were administered EORO by inhalation. Then, scopolamine was used to prepare Alzheimer's type dementia model mice. To evaluate cognitive function, the Y‐maze test was used for assessment of short‐term memory. EORO produced a significant improvement in the rate of spontaneous alternation behavior. Furthermore, 1,8‐cineole, α‐pinene, and β‐pinene, the main components of EORO, were detected in the brain in a concentration‐dependent manner following inhalation of EORO. Thus, inhalation of EORO may improve cognitive function in a model of Alzheimer's type dementia. Components such as 1,8‐cineole and others are likely involved in the effects on the brain. Examination of the detailed mechanism of action of EORO is necessary for future clinical application.

中文翻译：

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迷迭香吸入精油对东pol碱诱发的阿尔茨海默氏痴呆模型小鼠的影响

迷迭香的精油（迷迭香精油，EORO）可以通过激活中枢神经系统来改善认知功能。但是，尚未描述EORO效果的科学依据。因此，我们使用模型小鼠研究了EORO对阿尔茨海默氏型痴呆的影响。通过吸入对小鼠进行EORO。然后，用东pol碱制备阿尔茨海默氏型痴呆模型小鼠。为了评估认知功能，Y迷宫测试用于评估短期记忆。EORO大大提高了自发交替行为的速度。此外，吸入EORO后，在大脑中以浓度依赖的方式检测到EORO的主要成分1,8-桉树脑，α-，烯和β-pine烯。因此，在阿尔茨海默氏型痴呆模型中，吸入EORO可能会改善认知功能。1,8-桉树脑等成分可能与对大脑的影响有关。对EORO的详细作用机制进行检查对于将来的临床应用是必要的。