To generate the electrical communication, biocompatibility, and controlled cell attachment properties required for advanced bioelectronic technologies, a dynamic poly(3,4‐ethylenedioxythiophene) (PEDOT) film is developed based on a biomimetic approach. The dynamic PEDOT integrates low impedance, nonspecific‐binding resistance, and redox‐responsive characteristics while coupling with cells stably and specifically. The combination of these features ensures stable and efficient electrical communication with cells and promises potentially reduced disruption of complexes in physiological environments due to the material's strong resistance to nonspecific interactions; more significantly, the integration of these features in one material enables the spatiotemporal attachment and detachment of cells on demand without damage to cell viability and neurites after 5 d of electrical stimulation and culturing. The dynamic and biomimetic PEDOT material can be an ideal electronic interface with optimized electrochemical and biological characteristics toward biocompatible and controllable electrocoupling with cells at low impedance.

中文翻译：

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动态聚（3,4-乙撑二氧噻吩）s将低阻抗与氧化还原可切换生物功能整合在一起

为了产生先进生物电子技术所需的电通信，生物相容性和可控的细胞附着特性，基于仿生方法开发了动态聚（3,4-乙烯二氧噻吩）（PEDOT）薄膜。动态PEDOT集成了低阻抗，非特异性结合电阻和氧化还原响应特性，同时稳定且特异性地与细胞结合。这些特征的结合确保了与细胞的稳定有效的电通讯，并由于该材料对非特异性相互作用的强抵抗力，有望潜在地减少复合物在生理环境中的破坏。更重要的是，将这些特征整合到一种材料中后，可以按需时空附着和分离细胞，而在电刺激和培养5天后，不会损害细胞活力和神经突。动态且仿生的PEDOT材料可以是理想的电子界面，具有优化的电化学和生物学特性，可实现与低阻抗细胞的生物相容性和可控电耦合。