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Heterobimetallic Complexes for Theranostic Applications
Chemistry - A European Journal ( IF 4.3 ) Pub Date : 2018-02-12 , DOI: 10.1002/chem.201705335
Vanesa Fernández-Moreira 1 , M. Concepción Gimeno 1
Affiliation  

The design of more efficient anticancer drugs requires a deeper understanding of their biodistribution and mechanism of action. Cell imaging agents could help to gain insight into biological processes and, consequently, the best strategy for attaining suitable scaffolds in which both biological and imaging properties are maximized. A new concept arises in this field that is the combination of two metal fragments as collaborative partners to provide the precise emissive properties to visualize the cell as well as the optimum cytotoxic activity to build more potent and selective chemotherapeutic agents.

中文翻译:

用于治疗学的异双金属配合物

设计更有效的抗癌药物需要对它们的生物分布和作用机理有更深入的了解。细胞显像剂可以帮助深入了解生物学过程,因此,是获得最佳支架的最佳策略,在该支架中,生物学和成像特性均得到了最大化。在该领域中出现了一个新概念,即将两个金属片段作为合作伙伴进行组合,以提供精确的发射特性以可视化细胞,并提供最佳的细胞毒性活性以构建更有效和选择性的化学治疗剂。
更新日期:2018-02-12
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