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Improving immune–vascular crosstalk for cancer immunotherapy
Nature Reviews Immunology ( IF 100.3 ) Pub Date : 2018-01-15 , DOI: 10.1038/nri.2017.145
Yuhui Huang 1 , Betty Y S Kim 2 , Charles K Chan 3 , Stephen M Hahn 4 , Irving L Weissman 3 , Wen Jiang 4
Affiliation  

The vasculature of tumours is highly abnormal and dysfunctional. Consequently, immune effector cells have an impaired ability to penetrate solid tumours and often exhibit compromised functions. Normalization of the tumour vasculature can enhance tissue perfusion and improve immune effector cell infiltration, leading to immunotherapy potentiation. However, recent studies have demonstrated that the stimulation of immune cell functions can also help to normalize tumour vessels. In this Opinion article, we propose that the reciprocal regulation between tumour vascular normalization and immune reprogramming forms a reinforcing loop that reconditions the tumour immune microenvironment to induce durable antitumour immunity. A deeper understanding of these pathways could pave the way for identifying new biomarkers and developing more effective combination treatment strategies for patients with cancer.



中文翻译:

改善癌症免疫治疗的免疫-血管串扰

肿瘤的脉管系统高度异常且功能失调。因此,免疫效应细胞穿透实体瘤的能力受损,并且经常表现出功能受损。肿瘤脉管系统的正常化可以增强组织灌注并改善免疫效应细胞浸润,从而增强免疫治疗。然而,最近的研究表明,刺激免疫细胞功能也有助于肿瘤血管正常化。在这篇观点文章中,我们提出肿瘤血管正常化和免疫重编程之间的相互调节形成一个增强环,重新调节肿瘤免疫微环境以诱导持久的抗肿瘤免疫。对这些途径的更深入了解可以为识别新的生物标志物和为癌症患者开发更有效的联合治疗策略铺平道路。

更新日期:2018-01-15
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