A convenient and environmentally friendly protocol has been developed for the preparation of various sulfonylated 2(5H)-furanones by the sulfonylation of C_sp2–X compounds with sodium sulfinates via a metal-free radical pathway. For low-cost C_sp2–Cl substrates, there is also a satisfactory reactivity with moderate to excellent yields as well as high atom economy. Importantly, the application of this method into a gram-scale (even over 10 g) preparation can be accomplished.

中文翻译：

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在大气介质中通过自由基途径在空气介质下用亚磺酸钠进行3,4-二卤代-2（5 H）-呋喃酮（X = Cl，Br）的无金属磺酰化

已经开发了一种方便且环保的方案，用于通过金属自由基途径通过C _sp2- X化合物与亚磺酸钠的磺酰化反应来制备各种磺酰化的2（5 H）-呋喃酮。对于低成本的C _sp2 - Cl底物，还具有令人满意的反应性，具有中等至出色的产率以及高原子经济性。重要的是，可以将该方法应用于克级（甚至超过10 g）制剂中。