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Membrane insertion of-and membrane potential sensing by-semiconductor voltage nanosensors: Feasibility demonstration.
Science Advances ( IF 13.6 ) Pub Date : 2018-Jan-01 , DOI: 10.1126/sciadv.1601453
Kyoungwon Park 1 , Yung Kuo 1 , Volodymyr Shvadchak 2 , Antonino Ingargiola 1 , Xinghong Dai 3 , Lawrence Hsiung 4 , Wookyeom Kim 5 , Z. Hong Zhou 3, 6 , Peng Zou 7 , Alex J. Levine 1, 8 , Jack Li 1 , Shimon Weiss 1, 6, 9
Affiliation  

We developed membrane voltage nanosensors that are based on inorganic semiconductor nanoparticles. We provide here a feasibility study for their utilization. We use a rationally designed peptide to functionalize the nanosensors, imparting them with the ability to self-insert into a lipid membrane with a desired orientation. Once inserted, these nanosensors could sense membrane potential via the quantum confined Stark effect, with a single-particle sensitivity. With further improvements, these nanosensors could potentially be used for simultaneous recording of action potentials from multiple neurons in a large field of view over a long duration and for recording electrical signals on the nanoscale, such as across one synapse.

中文翻译:

通过半导体电压纳米传感器进行膜插入和膜电势感测:可行性论证。

我们开发了基于无机半导体纳米粒子的膜电压纳米传感器。我们在此提供有关其使用的可行性研究。我们使用合理设计的肽来使纳米传感器功能化,使其具有以所需方向自插入脂质膜的能力。一旦插入,这些纳米传感器就可以通过量子限制的Stark效应感测膜电位,并且具有单粒子敏感性。通过进一步的改进,这些纳米传感器可潜在地用于在长时间范围内同时记录大视野中多个神经元的动作电位,并用于记录纳米级的电信号,例如跨一个突触。
更新日期:2018-01-13
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