Abstract An ultrathin graphene oxide (GO) laminar composite membrane has been fabricated in-house via pressure-assisted filtration. It has a relatively high pure water permeability (PWP) of 7.70 LMH/bar with a molecular weight cut-off (MWCO) of 1243 Da. When being treated with various solvents, the membrane exhibits good stability in both polar and nonpolar solvents. The GO laminar composite membrane has relatively high pure solvent fluxes of 24.89 Lm−2h−1, 7.95 Lm−2h−1 and 12.08 Lm−2h−1 for ethanol, isopropanol and hexane, respectively. Its rejections to orange II sodium salt, safranin O, solvent blue 35, rhodamine B and remazol brilliant blue are 56.60%, 86.52%, 4.39%, 66.95% and 97.11%, respectively. Experimental results suggest that the Donnan exclusion is less effective in organic solvent nanofiltration (OSN) than in aqueous systems, while the size exclusion and solute-membrane affinity are the dominant factors in determining separation performance. Some active pharmaceutical ingredients (APIs) and food additives, e.g. tetracycline, rifampicin, roxithromycin, spiramycin, vitamin B12 and lecithin, are used to demonstrate the separation capability of the newly developed membrane in real-life applications. It can effectively retain those compounds with rejections of 65.80%, 82.67%, 84.27%, 92.21%, 95.34% and 98.44%, respectively. Several 7-day tests of vitamin B12 in isopropanol also confirm the membrane integrity and separation performance for continuous OSN uses.

中文翻译：

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用于在有机溶剂中浓缩药物和食品添加剂的氧化石墨烯 (GO) 层状膜

摘要 通过压力辅助过滤在内部制造了一种超薄氧化石墨烯 (GO) 层状复合膜。它具有相对较高的纯水渗透率 (PWP)，为 7.70 LMH/bar，截留分子量 (MWCO) 为 1243 Da。当用各种溶剂处理时，膜在极性和非极性溶剂中都表现出良好的稳定性。GO 层状复合膜对乙醇、异丙醇和己烷具有相对较高的纯溶剂通量，分别为 24.89 Lm-2h-1、7.95 Lm-2h-1 和 12.08 Lm-2h-1。其对橙Ⅱ钠盐、番红O、溶剂蓝35、罗丹明B和瑞马唑亮蓝的去除率分别为56.60%、86.52%、4.39%、66.95%和97.11%。实验结果表明，唐南排斥在有机溶剂纳滤 (OSN) 中不如在水性体系中有效，而尺寸排阻和溶质膜亲和力是决定分离性能的主要因素。一些活性药物成分 (API) 和食品添加剂，例如四环素、利福平、罗红霉素、螺旋霉素、维生素 B12 和卵磷脂，用于证明新开发的膜在实际应用中的分离能力。它可以有效地保留那些废品率分别为 65.80%、82.67%、84.27%、92.21%、95.34% 和 98.44% 的化合物。对异丙醇中的维生素 B12 进行的几项 7 天测试也证实了连续使用 OSN 时膜的完整性和分离性能。罗红霉素、螺旋霉素、维生素 B12 和卵磷脂用于证明新开发的膜在实际应用中的分离能力。它可以有效地保留那些废品率分别为 65.80%、82.67%、84.27%、92.21%、95.34% 和 98.44% 的化合物。对异丙醇中的维生素 B12 进行的几项 7 天测试也证实了连续使用 OSN 时膜的完整性和分离性能。罗红霉素、螺旋霉素、维生素 B12 和卵磷脂用于证明新开发的膜在实际应用中的分离能力。它可以有效地保留那些废品率分别为 65.80%、82.67%、84.27%、92.21%、95.34% 和 98.44% 的化合物。对异丙醇中的维生素 B12 进行的几项 7 天测试也证实了连续使用 OSN 时膜的完整性和分离性能。