In the fine chemical industry, new production processes are often implemented in multipurpose existing plants with minimum adaptation investments. When the new process involves a potential runaway reaction, a full thermodynamic and kinetic characterization of the system should be performed to evaluate whether the reaction can be safely scaled-up in the selected plant. However, a detailed kinetic characterization is often unsuited because of the huge development rate of new products. In this work a potential runaway reaction of the agrochemical industry, that is, the nitration of 2,4-dichloro benzotrifluoride through mixed acids, is investigated with the aim of implementing it with a minimum experimental effort in an existing plant already dedicated to a similar reaction, that is, the nitration of 4-chloro benzotrifluoride. It has been shown that, even performing very similar reactions, the Ψ number criterion cannot be implemented in a univocal way to monitor the multipurpose SBR operation. Such a goal can instead be reached through the general procedure based on the Ψ, X, and MTSR_ad set of process indicators, which was previously applied to the monitoring of polymerization processes.

中文翻译：

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多用途工厂中精细化学失控反应的简单监控：2，4-二氯苯三氟化物的硝化

在精细化工行业中，新生产工艺通常在具有最小适应性投资的多功能现有工厂中实施。当新工艺涉及潜在的失控反应时，应对系统进行全面的热力学和动力学表征，以评估反应是否可以在选定的工厂中安全放大。但是，由于新产品的巨大发展速度，通常不适合进行详细的动力学表征。在这项工作中，研究了农业化学工业的潜在失控反应，即通过混合酸硝化2,4-二氯苯并三氟甲烷，目的是以最小的实验努力在已经专门从事类似工作的现有工厂中实施该反应。反应，即4-氯三氟甲苯的硝化反应。事实证明，即使执行非常相似的反应，也不能以明确的方式实施Ψ数准则来监视多用途SBR操作。相反，可以通过基于Ψ的一般过程来实现此目标，X和MTSR_广告集的过程指标，这是以前施加于聚合过程的监测。