Candidatus Liberibacter asiaticus (CLas) is the presumed causal agent of Huanglongbing, one of the most destructive diseases in citrus. However, the lipid metabolism component of host response to this pathogen has not been investigated well. Here, metabolic profiling of a variety of long-chain fatty acids and their oxidation products was first performed to elucidate altered host metabolic responses of disease. Fatty acid signals were found to decrease obviously in response to disease regardless of cultivar. Several lipid oxidation products strongly correlated with those fatty acids were also consistently reduced in the diseased group. Using a series of statistical methods and metabolic pathway mapping, we found significant markers contributing to the pathological symptoms and identified their internal relationships and metabolic network. Our findings suggest that the infection of CLas may cause the altered metabolism of long-chain fatty acids, possibly leading to manipulation of the host’s defense derived from fatty acids.

中文翻译：

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代谢分析揭示了黄龙病对宿主体内长链脂肪酸代谢的影响

暂定Liberibacter胭脂（ÇLas）是黄龙病的推定病因，黄龙病是柑橘中最具破坏性的疾病之一。但是，宿主对这种病原体应答的脂质代谢成分尚未得到很好的研究。在这里，首先对各种长链脂肪酸及其氧化产物进行代谢分析，以阐明疾病的宿主代谢反应的改变。无论品种如何，脂肪酸信号均会因疾病而明显降低。与那些脂肪酸强烈相关的几种脂质氧化产物在患病组中也持续降低。使用一系列统计方法和代谢途径作图，我们发现了导致病理症状的重要标志物，并确定了它们的内部关系和代谢网络。我们的发现表明，C Las可能会引起长链脂肪酸代谢的改变，可能导致操纵源自脂肪酸的宿主防御能力。