Chemical decontamination of iPS cell-derived neural cell mixtures,Chemical Communications

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Chemical decontamination of iPS cell-derived neural cell mixtures
Chemical Communications ( IF 4.9 ) Pub Date : 2018-01-12 00:00:00 , DOI: 10.1039/c7cc08686e
Di Mao _{1,

2,

3,

4} , Xie Khim Watson Chung _{1,

2,

3,

4} , Tomoko Andoh-Noda _{4,

5,

6,

7,

8} , Ying Qin _{1,

2,

3,

4} , Shin-ichi Sato _{1,

2,

3,

4} , Yasushi Takemoto _{1,

2,

3,

4} , Wado Akamatsu _{4,

5,

6,

7,

8} , Hideyuki Okano _{4,

5,

6,

7,

8} , Motonari Uesugi _{1,

2,

3,

4}

Affiliation

This report describes the design and evaluation of phosphorylated 7-ethyl-10-hydroxycamptothecin (SN38-P), which selectively eliminates tumor-forming proliferative stem cells, including human induced pluripotent stem cells (hiPSCs) and neural stem cells, from iPSC-derived neural cell mixtures. Results of the present study demonstrate that simple phosphorylation of an anticancer drug can provide a safe, cost-effective, and chemically-defined tool for decontaminating hiPSC-derived neuron.

中文翻译：

iPS细胞衍生的神经细胞混合物的化学净化

本报告描述了磷酸化7-乙基-10-羟基喜树碱（SN38-P）的设计和评估，该磷酸化可选择性地消除iPSC衍生的肿瘤形成性增殖干细胞，包括人诱导的多能干细胞（hiPSC）和神经干细胞。神经细胞混合物。本研究的结果表明，抗癌药物的简单磷酸化可以为去污hiPSC衍生的神经元提供安全，经济高效且化学性质明确的工具。

更新日期：2018-02-02

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