An efficient and practical de novo synthesis of pyrrole-2-carbaldehyde skeletons featuring oxidative annulation and C_sp3–H to C═O oxidation is presented, exemplified by the preparation of pyrrole-2-carbaldehyde derivatives from aryl methyl ketones, arylamines, and acetoacetate esters. Preliminary mechanistic investigations indicate that the aldehyde oxygen atom originates from oxygen. Moreover, the developed scalable approach provides a distinct advantage over traditional oxidative functionalization of C–H moieties, avoiding the use of stoichiometric quantities of hazardous oxidants.

中文翻译：

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氧化环化和C _sp 3–H直接氧化为C═O合成吡咯-2-甲醛衍生物

提出了一种高效且实用的从头合成吡咯-2-甲醛骨架的方法，该骨架具有氧化环化反应和C _sp 3–H到C═O氧化反应，以由芳基甲基酮，芳基胺和乙酰乙酸酯。初步的机理研究表明，醛中的氧原子起源于氧。此外，已开发的可扩展方法相对于C–H部分的传统氧化功能化具有明显优势，避免了使用化学计量的危险氧化剂。