A novel sulfonated C₂₀-diterpenoid alkaloid with an unprecedented carbon skeleton and significant analgesic activity (46.7% inhibition at 0.1 mg/kg, i.p.), named aconicarmisulfonine A (1), was isolated from an aqueous extract of the lateral roots of Aconitum carmichaelii. Its structure was determined by comprehensive analysis of spectroscopic data, especially by 2D NMR spectroscopic data combined with ECD calculation and single-crystal X-ray diffraction. The plausible biosynthetic pathways of compound 1 are also discussed.

中文翻译：

---

Aconicarmisulfonine A，磺化Ç ₂₀ -Diterpenoid生物碱的侧根附子

从乌头侧柏根部的水提物中分离出一种新型的磺化的C _20-二萜生物碱，其具有前所未有的碳骨架和显着的镇痛活性（0.1 mg / kg，ip时抑制率达46.7％），被命名为乌头酸二磺酸A（1）。。它的结构是通过对光谱数据进行综合分析确定的，特别是通过结合ECD计算和单晶X射线衍射的2D NMR光谱数据确定的。还讨论了化合物1的合理生物合成途径。