The Mycobacterium tuberculosis genome encodes twenty cytochrome P450 enzymes, most or all of which appear to have specific physiological functions rather than being devoted to the removal of xenobiotics. However, in many cases their specific functions remain obscure. Considerable spectroscopic, biophysical, crystallographic, and catalytic information is available on nine of these cytochrome P450 enzymes, although gaps exist in our knowledge of even these enzymes. The available evidence indicates that at least three of the better-characterized enzymes are promising targets for antituberculosis drug discovery. This review summarizes the information on the nine relatively well-characterized cytochrome P450 enzymes, with a particular emphasis on CYP121, CYP125, and CYP142 from Mycobacterium tuberculosis and Mycobacterium smegmatis.

在结核分枝杆菌基因组编码20种细胞色素P450酶，大部分或所有这些似乎具有特定的生理功能，而不是专门用于去除生物异源物质的。但是，在许多情况下，它们的特定功能仍然不清楚。关于其中9种细胞色素P450酶，可以获得相当多的光谱，生物物理，晶体学和催化信息，尽管我们对这些酶的认识还存在差距。现有证据表明，至少三种更好的酶是抗结核药物发现的有希望的靶标。这篇综述总结了关于九种相对较好表征的细胞色素P450酶的信息，特别着重于CYP121，CYP125和CYP142。结核分枝杆菌和耻垢分枝杆菌。