Dendrimers, which are considered as one of the most promising tools in the field of nanobiotechnology due to their structural organization, showed a great potential in gene therapy, drug delivery, medical imaging and as antimicrobial and antiviral agents. This article is devoted to study interactions between new carbosilane-based metallodendrimers containing ruthenium and anti-cancer small interfering RNA (siRNA). Formation of complexes between anti-cancer siRNAs and Ru-based carbosilane dendrimers was evaluated by transmission electron microscopy, circular dichroism and fluorescence. The zeta-potential and the size of dendriplexes were determined by dynamic light scattering. The internalization of dendriplexes were estimated using HL-60 cells. Results show that ruthenium dendrimers associated with anticancer siRNA have the ability to deliver siRNA as non-viral vectors into the cancer cells. Moreover, dendrimers can protect siRNA against nuclease degradation. Nevertheless, further research need to be performed to examine the therapeutic potential of ruthenium dendrimers as well as dendrimers complexed with siRNA and anticancer drugs towards cancer cells.

由于大分子的结构组织，其被认为是纳米生物技术领域中最有前途的工具之一，在基因治疗，药物递送，医学成像以及作为抗微生物剂和抗病毒剂方面显示出巨大的潜力。本文致力于研究含钌的基于碳硅烷的新型金属树枝状大分子与抗癌小干扰RNA（siRNA）之间的相互作用。通过透射电子显微镜，圆二色性和荧光评价了抗癌siRNA和Ru基碳硅烷树状大分子之间复合物的形成。树突状电位的ζ电位和大小通过动态光散射测定。使用HL-60细胞评估树突状复合物的内在化。结果表明，与抗癌siRNA相关的钌树枝状聚合物具有将siRNA作为非病毒载体传递到癌细胞中的能力。此外，树枝状大分子可以保护siRNA免受核酸酶降解。然而，需要进行进一步的研究以检查钌树枝状大分子以及与siRNA和抗癌药物复合的树枝状大分子对癌细胞的治疗潜力。