Bisphenol A (BPA) has been well documented for its endocrine disrupting potential however, very little is known about endocrine disrupting abilities of bisphenol S (BPS). The present study aimed to compare the endocrine disrupting potentials of BPS with BPA, using female rats as an experimental animal model. On postnatal day 1 (PND 1) female pups born were randomly assigned to seven different treatments. Control group received subcutaneous injection of castor oil (50 μL) from PND 1 to PND 10. Three groups of female pups were injected subcutaneously with different concentrations (0.5, 5 and 50 mg/kg in 50 μL castor oil) of BPS, while remaining three groups were treated with 0.5, 5 and 50 mg/kg BPA. Highest doses treatments of both compounds resulted in delayed puberty onset and altered estrous cyclicity. Final body weight was significantly high in the highest dose treated groups of both BPS and BPA. Gonadosomatic index, absolute and relative weight of uteri was significantly reduced in BPS (5 and 50 mg/kg) and BPA (5 and 50 mg/kg) treated groups than control. Plasma concentrations of testosterone and estradiol were significantly increased, while plasma progesterone, Luteinizing hormone (LH) and Follicle stimulating hormone (FSH) concentrations were significantly reduced in highest doses treated groups. Dose dependent increase in the number of cystic follicles in the ovaries was evident along with an increase in the number of atratic follicles. The results suggest that neonatal exposure to higher concentrations of BPS can lead to BPA like structural and endocrine alterations in female rats.

双酚A（BPA）的内分泌干扰潜力已被充分证明，然而，关于双酚S（BPS）的内分泌干扰能力知之甚少。本研究旨在使用雌性大鼠作为实验动物模型，比较BPS与BPA的内分泌干扰潜能。在出生后第1天（PND 1），将出生的雌性幼崽随机分配给7种不同的治疗方法。对照组从PND 1到PND 10皮下注射蓖麻油（50μL）。三组雌性幼崽皮下注射不同浓度的BPS（50μL蓖麻油中分别为0.5、5和50 mg / kg），同时其余三组分别接受0.5、5和50 mg / kg BPA的治疗。两种化合物的最高剂量治疗均导致青春期发作延迟和发情周期改变。在BPS和BPA的最高剂量治疗组中，最终体重显着较高。与对照组相比，BPS（5和50 mg / kg）和BPA（5和50 mg / kg）治疗组的性腺体指数，子宫绝对和相对体重显着降低。在最高剂量治疗组中，血浆睾酮和雌二醇的浓度显着增加，而血浆孕酮，促黄体生成激素（LH）和促卵泡激素（FSH）的浓度显着降低。卵巢中囊性卵泡数目的剂量依赖性增加是明显的，而离体卵泡数目的增加也是明显的。结果表明，新生儿暴露于较高浓度的BPS可以导致雌性大鼠中BPA的结构和内分泌改变。与对照组相比，BPS（5和50 mg / kg）和BPA（5和50 mg / kg）治疗组的性腺体指数，子宫绝对和相对体重显着降低。在最高剂量治疗组中，血浆睾酮和雌二醇的浓度显着增加，而血浆孕酮，促黄体生成激素（LH）和促卵泡激素（FSH）的浓度显着降低。卵巢中囊性卵泡数目的剂量依赖性增加是明显的，而离体卵泡数目的增加也是明显的。结果表明，新生儿暴露于较高浓度的BPS可以导致雌性大鼠中BPA的结构和内分泌改变。与对照组相比，BPS（5和50 mg / kg）和BPA（5和50 mg / kg）治疗组的性腺体指数，子宫绝对和相对体重显着降低。在最高剂量治疗组中，血浆睾酮和雌二醇的浓度显着增加，而血浆孕酮，促黄体生成激素（LH）和促卵泡激素（FSH）的浓度显着降低。卵巢中囊性卵泡数目的剂量依赖性增加是明显的，而离体卵泡数目的增加也是明显的。结果表明，新生儿暴露于较高浓度的BPS可以导致雌性大鼠中BPA的结构和内分泌改变。在最高剂量治疗组中，血浆睾酮和雌二醇的浓度显着增加，而血浆孕酮，促黄体生成激素（LH）和促卵泡激素（FSH）的浓度显着降低。卵巢中囊性卵泡数目的剂量依赖性增加是明显的，而离体卵泡数目的增加也是明显的。结果表明，新生儿暴露于较高浓度的BPS可以导致雌性大鼠中BPA的结构和内分泌改变。在最高剂量治疗组中，血浆睾酮和雌二醇的浓度显着增加，而血浆孕酮，促黄体生成激素（LH）和促卵泡激素（FSH）的浓度显着降低。卵巢中囊性卵泡数目的剂量依赖性增加是明显的，而离体卵泡数目的增加也是明显的。结果表明，新生儿暴露于较高浓度的BPS可以导致雌性大鼠中BPA的结构和内分泌改变。卵巢中囊性卵泡数目的剂量依赖性增加是明显的，而离体卵泡数目的增加也是明显的。结果表明，新生儿暴露于较高浓度的BPS可以导致雌性大鼠中BPA的结构和内分泌改变。卵巢中囊性卵泡数目的剂量依赖性增加是明显的，而离体卵泡数目的增加也是明显的。结果表明，新生儿暴露于较高浓度的BPS可以导致雌性大鼠中BPA的结构和内分泌改变。