The development of highly sensitive and selective enantiomeric platforms towards the rapid screening of active pharmaceutical ingredients (APIs) is nowadays a crucial challenge in several fields related to pharmacology, biomedicine, biotechnology and (bio)sensors. Herein, it is presented a novel, facile and generic methodology focused on exploiting the synergistically and electrocatalytic properties of chiral magnetic-nanobiofluids (mNBFs) with electrochemical enantiobiosensing at a magneto nanocomposite graphene paste electrode (mNC–GPE). The feasibility of this approach has been validated by chirally recognizing tryptophan (TRP) enantiomers as a proof-of-concept. For this aim, a specific chiral mNBF based on an aqueous dispersion of cobalt ferrite loaded with gold nanoparticles carrying a thiolated β-cyclodextrin (β–CD-SH/Au/CoFe₂O₄–NPs) has been synthesized and used towards the supramolecular discrimination of TRP enantiomers at an advanced graphene-paste transducer via cyclic voltammetry. This strategy, which is the first demonstration of applicability of chiral mNBFs for electrochemical enantiorecognition, opens up new approaches into enantio(bio)sensing.

如今，在药理学，生物医学，生物技术和（生物）传感器相关的几个领域中，开发用于快速筛选活性药物成分（API）的高灵敏度和选择性对映异构体平台是一项严峻的挑战。本文介绍了一种新颖，简便，通用的方法，该方法致力于利用手性磁性纳米生物流体（mNBF）在磁性纳米复合石墨烯糊状电极（mNC–GPE）上的电化学对映增强的协同和电催化特性。通过手性识别色氨酸（TRP）对映体作为概念验证，已验证了该方法的可行性。为了这个目的，一种特定的手性mNBF是基于钴铁氧体的水分散体，负载有载有硫醇化的β-环糊精的金纳米颗粒（β-CD-SH/ Au / CoFe已合成₂ O ₄ -NPs，并通过循环伏安法将其用于高级石墨烯-糊剂传感器中的TRP对映体的超分子鉴别。该策略是手性mNBFs在电化学对映体识别中的适用性的首次证明，它为对映（生物）传感开辟了新的途径。