An innovative drug-loaded colloidal hydrogel was synthesized for applications in neural interfaces in tissue engineering by reacting carboxyl capped aniline dimer and gelatin molecules. Dexamethasone was loaded into the gelatin-aniline dimer solution as a model drug to form an in situ drug-loaded colloidal hydrogel. The conductivity of the hydrogel samples fluctuated around 10⁻⁵ S/cm which appeared suitable for cellular activities. Cyclic voltammetry was used for electroactivity determination, in which 2 redox states were observed, suggesting that the short chain length and steric hindrance prevented the gel from achieving a fully oxidized state. Rheological data depicted the modulus decreasing with aniline dimer increment due to limited hydrogen bonds accessibility. Though the swelling ratio of pristine gelatin (600%) decreased by the introduction and increasing the concentration of aniline dimer because of its hydrophobic nature, it took the value of 300% at worst, which still seems promising for drug delivery uses. Degradation rate of hydrogel was similarly decreased by adding aniline dimer. Drug release was evaluated in passive and stimulated patterns demonstrating tendency of aniline dimer to form a vesicle that controls the drug release behavior. The optimal cell viability, proper cell attachment and neurite extension was achieved in the case of hydrogel containing 10 wt% aniline dimer. Based on tissue/organ behavior, it was promisingly possible to adjust the characteristics of the hydrogels for an optimal drug release. The outcome of this simple and effective approach can potentially offer additional tunable characteristics for recording and stimulating purposes in neural interfaces.

通过使羧基封端的苯胺二聚体和明胶分子反应，合成了一种创新的载有药物的胶体水凝胶，可用于组织工程的神经界面。将地塞米松作为模型药物加载到明胶-苯胺二聚体溶液中，以形成原位加载药物的胶体水凝胶。水凝胶样品的电导率在10 ^-5左右波动 S / cm似乎适合细胞活动。循环伏安法用于电活性测定，其中观察到2个氧化还原状态，表明短链长和位阻阻碍了凝胶达到完全氧化状态。流变数据描述了由于有限的氢键可及性，模量随苯胺二聚体的增加而降低。尽管由于其疏水性，原始明胶的溶胀率（600％）由于引入苯胺二聚体并增加其浓度而降低，但最坏情况下其溶胀率为300％，这似乎仍有望用于药物输送。加入苯胺二聚体同样降低了水凝胶的降解速率。以被动和刺激模式评估药物释放，表明苯胺二聚体形成控制药物释放行为的囊泡的趋势。在含有10wt％苯胺二聚体的水凝胶的情况下，获得了最佳的细胞生存力，适当的细胞附着和神经突延伸。基于组织/器官的行为，有可能调整水凝胶的特性以获得最佳药物释放。这种简单有效的方法的结果可能会为神经接口中的记录和刺激目的提供其他可调特性。有可能调整水凝胶的特性以获得最佳药物释放。这种简单有效的方法的结果可能会为神经接口中的记录和刺激目的提供其他可调特性。有可能调整水凝胶的特性以获得最佳药物释放。这种简单有效的方法的结果可能会为神经接口中的记录和刺激目的提供其他可调特性。