The inhibitory potential of Montmorency tart cherry on glycemia regulation and other enzymes relevant to inflammation were evaluated. Tart cherry has superior inhibitory potential against key enzymes associated with carbohydrate digestion linked to hypertension. In particular, α-amylase activity was significantly inhibited (IC50 = 3.46 ± 0.06 mg/ml), whereas we observed mild inhibition of α-glucosidase (IC50 = 11.64 ± 0.65 mg/ml). Angiotensin I-converting enzyme inhibition was also strong by about 89%. Tart cherry extract showed strong to moderate inhibitions of cyclooxygenase-1 (65%), lipoxygenase (64%), cyclooxygenase-2 (38%) and xanthine oxidase (26%), respectively. Anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, were strong inhibitors of α-amylase and α-glucosidase. Kaempferol showed relatively potent inhibition on COX and XO. It was revealed that some pairs of metabolites manifest positive or negative interactions against XO enzyme inhibition. Inhibition of all these enzymes provides a strong biochemical basis for management of type 2 diabetes and cardiovascular disease by controlling glucose absorption, reducing associated hypertension and inflammation.

评估了蒙莫朗西酸樱桃对血糖调节和与炎症相关的其他酶的抑制潜力。酸樱桃对与高血压相关的碳水化合物消化有关的关键酶具有极强的抑制潜力。特别是，α-淀粉酶活性被显着抑制（IC50 = 3.46±0.06 mg / ml），而我们观察到对α-葡萄糖苷酶的轻度抑制（IC50 = 11.64±0.65 mg / ml）。血管紧张素I转换酶的抑制作用也很强，约为89％。酸樱桃提取物分别显示出对环氧合酶1（65％），脂氧合酶（64％），环氧合酶2（38％）和黄嘌呤氧化酶（26％）的强至中度抑制作用。花青素，花青素3-芸苔苷和花青素3-葡糖苷是α-淀粉酶和α-葡糖苷酶的强抑制剂。山emp酚对COX和XO显示出相对有效的抑制作用。揭示了一些代谢物对XO酶抑制表现出正或负的相互作用。通过控制葡萄糖的吸收，减少相关的高血压和炎症，抑制所有这些酶为2型糖尿病和心血管疾病的治疗提供了强大的生化基础。