Association of fatty acids and lipids metabolism in placenta with early spontaneous pregnancy loss in Chinese women,Food & Function

当前位置： X-MOL 学术 › Food Funct. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Association of fatty acids and lipids metabolism in placenta with early spontaneous pregnancy loss in Chinese women
Food & Function ( IF 6.1 ) Pub Date : 2018-01-12 00:00:00 , DOI: 10.1039/c7fo01545c
Kelei Li _{1,

2,

3,

4,

5} , Xiaotian Zhang _{6,

7,

8,

9,

10} , Gong Chen _{4,

10,

11,

12} , Lijun Pei _{4,

10,

11,

12} , Hailong Xiao _{4,

13,

14} , Jiajing Jiang _{4,

5,

14,

15} , Jiaomei Li _{4,

5,

14,

15} , Xiaoying Zheng _{4,

10,

11,

12} , Duo Li _{1,

2,

3,

4,

5}

Affiliation

Institute of Nutrition and Health
Qingdao University
Qingdao
China
Department of Food Science and Nutrition
The Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education
Institute of Cell Biology
College of Life Sciences
Beijing Normal University
Beijing
Institute of Population Research/WHO Collaborating Center on Reproductive Health and Population Science
Peking University
Hangzhou Institute for Food and Drug Control
Hangzhou
Zhejiang University

The aim of the present study was to evaluate the association of fatty acids and lipids metabolism in placenta with early spontaneous pregnancy loss (ESPL) in Chinese women. Seventy women with ESPL and 29 healthy pregnant women who asked for legal induced abortion were included in the case and control groups, respectively. The gestational age of the subject foetuses in both the case and control groups ranged from 4 to 10 weeks. The total fatty acids composition in the decidual and villous tissues was detected by gas–liquid chromatography using a standard method. Metabonomics analysis of the decidual and villous tissues was conducted by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-QTOFMS). The total C18:3n-3 in the decidual and villous tissues, total n-3 polyunsaturated fatty acid (n-3 PUFA) in the decidual tissue, and total C18:2n-6 in the villous tissue were all significantly lower in the case group than in the control group. The ratio of C20:4n-6/C20:5n-3 in villous tissue was significantly higher, but prostaglandin I₂ as well as hydroxyeicosapentaenoic acid, leukotriene B₅ and thromboxane B₃ in the villous tissue were significantly lower in the case group than in the control group. In addition, the low content of lysophosphatide in the decidual and villous tissues and the low content of diacylglycerol in the villous tissue were also associated with the occurance of ESPL. In conclusion, the lack of essential fatty acids, high ratio of C20:4n-6/C20:5n-3, abnormal eicosanoids metabolism and low content of lysophosphatide and diacylglycerol in the placenta were all potential risk factors for ESPL in Chinese.

更新日期：2018-01-12

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>