Graphene oxide (GO) attracts considerable attention for biomedical applications owing to its unique nanostructure and remarkable physicochemical characteristics. However, it is challenging to uniformly deposit GO on chemically inert Ti scaffolds, which have good biocompatibility and wide applications in bone engineering. In this study, a GO-functionalized Ti porous scaffold (GO/Ti scaffold) was prepared by depositing GO onto polydopamine (PDA) modified Ti scaffolds. The mussel-inspired PDA modification facilitated the interaction between GO and Ti surfaces, leading to a uniform coverage of GO on Ti scaffolds. BMP2 and vancomycin (Van) were separately encapsulated into gelatin microspheres (GelMS). Then, drug-containing GelMS were assembled on GO/Ti scaffolds and anchored by the functional groups of GO. The modified scaffold independently delivered multiple biomolecules with different physiochemical properties, without interfering with each other. Thus, the GO/Ti scaffold has the dual functions of inducing bone regeneration and preventing bacterial infection. In summary, this mussel-inspired GO/Ti hybrid scaffold combined the good mechanical properties of Ti scaffolds and the advantages of GO nanosheets. GO nanosheets with their unique nanostructure and functional groups, together with GelMS on Ti scaffolds, are suitable carriers for drug delivery and provide adhesive sites for cell adhesion and create nanostructured environments for bone regeneration.

中文翻译：

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贻贝启发的氧化石墨烯纳米片包裹的Ti支架与药物包裹的明胶微球体一起用于骨骼再生†

氧化石墨烯（GO）由于其独特的纳米结构和卓越的理化特性而在生物医学领域引起了广泛关注。然而，将GO均匀地沉积在化学惰性的Ti支架上具有挑战性，该支架具有良好的生物相容性并在骨骼工程中具有广泛的应用。在这项研究中，通过将GO沉积到聚多巴胺（PDA）修饰的Ti支架上来制备GO功能化的Ti多孔支架（GO / Ti支架）。贻贝启发的PDA修饰促进了GO和Ti表面之间的相互作用，导致GO在Ti支架上均匀覆盖。将BMP2和万古霉素（Van）分别封装到明胶微球（GelMS）中。然后，将含药的GelMS组装在GO / Ti支架上，并通过GO的官能团锚定。修饰的支架独立地递送具有不同理化性质的多个生物分子，而不会彼此干扰。因此，GO / Ti支架具有诱导骨再生和防止细菌感染的双重功能。总而言之，这种贻贝启发的GO / Ti混合支架结合了Ti支架的良好机械性能和GO纳米片的优势。具有其独特的纳米结构和功能基团的GO纳米片以及在Ti支架上的GelMS都是用于药物输送的合适载体，并提供了用于细胞粘附的粘合位点，并创建了用于骨骼再生的纳米结构环境。GO / Ti支架具有诱导骨骼再生和防止细菌感染的双重功能。总而言之，这种贻贝启发的GO / Ti混合支架结合了Ti支架的良好机械性能和GO纳米片的优势。具有其独特的纳米结构和功能基团的GO纳米片以及在Ti支架上的GelMS都是用于药物输送的合适载体，并提供了用于细胞粘附的粘附位点，并为骨再生创造了纳米结构的环境。GO / Ti支架具有诱导骨骼再生和防止细菌感染的双重功能。总而言之，这种贻贝启发的GO / Ti混合支架结合了Ti支架的良好机械性能和GO纳米片的优势。具有其独特的纳米结构和功能基团的GO纳米片以及在Ti支架上的GelMS都是用于药物输送的合适载体，并提供了用于细胞粘附的粘合位点，并创建了用于骨骼再生的纳米结构环境。