Utilizing the size‐dependent adsorption properties of ruthenium carbonyl clusters (Ru–carbon monoxide (CO)) onto graphene oxide (GO), a facile CO‐release platform for in situ vasodilation as a treatment for stroke‐related vascular diseases is developed. The rate and amount of formation of the CO‐release‐active Ru^II(CO)₂ species can be modulated by a simple mixing procedure at room temperature. The subsequent thermally induced oxidation of Ru^II(CO)₂ to RuO₂ on the GO surface results in the release of CO. Further modulation of thermal and CO‐release properties can be achieved via a hybridization of medium‐ and high‐nuclearity of Ru–CO clusters that produces a RuO₂/Ru^II(CO)₂/⁶Ru–CO–GO composite, where ⁶Ru–CO–GO provides a photothermally activated reservoir of Ru^II(CO)₂ species and the combined infrared absorption properties of GO and RuO₂ provides photothermal response for in situ CO‐release. The RuO₂/Ru^II(CO)₂/⁶Ru–CO–GO composite does not produce any cytotoxicity and the efficacy of the composite is further demonstrated in a cortical photothrombotic ischemia rat model.

中文翻译：

---

利用氧化石墨烯上的金属羰基簇的各种核，灵活调节CO释放，以中风修复

利用羰基钌簇（Ru-一氧化碳（CO））在氧化石墨烯（GO）上的尺寸依赖性吸附特性，开发了一种用于原位血管舒张的简便的CO释放平台，以治疗中风相关的血管疾病。可以通过在室温下简单的混合程序来调节CO释放活性Ru ^II（CO）₂物种的形成速率和数量。随后在GO表面将Ru ^II（CO）₂热氧化为RuO ₂导致CO的释放。通过中，高核Ru的杂交可以实现热和CO释放特性的进一步调节–CO团簇产生RuO ₂ / Ru ^II（CO）₂ / ⁶的Ru-CO-GO复合材料，其中⁶的Ru-CO-GO提供Ru组成的光热激活贮存器^II（CO）₂种和GO和的RuO的组合红外线吸收性能₂提供了用于在原位光热响应共同释放。所述的RuO ₂ /钌^II（CO）₂ / ⁶的Ru-CO-GO复合材料不产生任何毒性和复合材料的功效在皮质光化学缺血大鼠模型被进一步证实。