Creating an intelligent artificial cell wall to endow fabricated cells with more advanced functionalities is highly desirable. Here, an efficient and cytocompatible approach to generate a type of viable artificial cell wall based on direct self‐assembly of coacervate microdroplets on individual cellular surface is developed, which can protect the fabricated cell against various external stresses and can then prolong the storage of the fabricated cells over two months. Moreover, as a type of viable artificial cell wall, it can not only help the fabricated cell sequester nutrients or functionalized substances such as catalase, or iron oxide nanoparticles actively from the solution which then makes the fabricated cell more versatile but also allows the fabricated cell proliferate. Significantly, the artificial cell wall also shows heritable behavior that can reserve its protection to as far as the third‐generation daughter cell. Undoubtedly, such an illustrated artificial cell wall provides a conceptually new and promising technique toward the cell‐based research as well as application of next generation.

中文翻译：

---

将凝聚微滴原位自组装成具有遗传力的可行人工细胞壁

迫切需要创建智能的人造细胞壁，以赋予人造细胞更多高级功能。在此，开发了一种有效的且具有细胞相容性的方法，该方法可基于凝聚微滴在各个细胞表面上的直接自组装来生成一种可行的人造细胞壁，这种方法可以保护所制造的细胞免受各种外部压力的影响，从而延长其储存时间。在两个月内捏造了电池。而且，作为一种可行的人造细胞壁，它不仅可以帮助溶液有效地隔离细胞中的营养物质或功能化物质（例如过氧化氢酶）或氧化铁纳米颗粒，从而使细胞更加通用，还可以使细胞得以生长增生。显着地，人造细胞壁还显示出可遗传的行为，可以保留其保护作用，直至第三代子细胞。毫无疑问，这样的人工细胞壁插图为基于细胞的研究以及下一代应用提供了一种概念上新的有前途的技术。