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Novel tricyclic diamines 1. Synthesis of 1,4-diazaisotwistane and 1,4-diazahomoisotwistane as constrained 3-aminoquinuclidine isosteres
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2018-01-11 , DOI: 10.1016/j.tetlet.2018.01.032 Ivar M. McDonald , Alicia Ng , Jingfang Cutrone , Robert Mate , Richard E. Olson
中文翻译:
新型三环二胺1.受约束的3-氨基喹核环烷等排体的合成1,4-二氮杂异twistane和1,4-二氮杂异twistane
更新日期:2018-01-11
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2018-01-11 , DOI: 10.1016/j.tetlet.2018.01.032 Ivar M. McDonald , Alicia Ng , Jingfang Cutrone , Robert Mate , Richard E. Olson
Synthesis of the novel tricyclic diamines 1,4-diazaisotwistane and 1,4-diazahomoisotwistane are described. These compact tricyclic cores have one tertiary and one secondary amine and may serve as ring-constrained isosteres of 3-aminoquinuclidine. Both tricycles were prepared by a similar strategy involving saturation of an appropriately substituted aromatic azaindole, functionalization and intramolecular alkylation.
中文翻译:
新型三环二胺1.受约束的3-氨基喹核环烷等排体的合成1,4-二氮杂异twistane和1,4-二氮杂异twistane
描述了新型三环二胺1,4-二氮杂异twistane和1,4-二氮杂高异twistane的合成。这些紧密的三环核具有一个叔胺和一个仲胺,并且可以作为3-氨基喹核环的环约束的等排体。两种三环化合物都是通过类似的策略制备的,包括适当取代的芳族氮杂吲哚的饱和,官能化和分子内烷基化。