Synthesis of the previously unreported 1,4-diazaadamantane is described. The overall strategy involves complete saturation of a flat, aromatic heterocycle, appropriate functionalization and intramolecular double alkylation. The alkylation takes place via an iminophosphorane under anhydrous conditions, which produced superior results vs. alkylation of the corresponding primary amine.

中文翻译：

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新型三环二胺3. 1,4-二氮杂金刚烷的合成

描述了先前未报道的1，4-二氮杂金刚烷的合成。总体策略包括完全饱和一个平坦的芳族杂环，适当的官能化和分子内双烷基化。烷基化是通过亚氨基磷烷在无水条件下进行的，与相应的伯胺的烷基化相比，该方法产生了优异的结果。