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A catalyst-free intermolecular trans-iodoalkylation of alkynes†
Organic & Biomolecular Chemistry ( IF 3.2 ) Pub Date : 2018-01-11 00:00:00 , DOI: 10.1039/c7ob03159a
Jie-Jie Liu 1, 2, 3, 4, 5 , Hong-Yan Huang 1, 2, 3, 4, 5 , Liang Cheng 1, 2, 3, 4, 5 , Qi Liu 1, 2, 3, 4, 5 , Dong Wang 1, 2, 3, 4, 5 , Li Liu 1, 2, 3, 4, 5
Affiliation  

We report the first catalyst-free and trans-selective iodoalkylation reaction of alkynes with a series of α-carbonyl compounds. This unprecedented three-component iodoalkylation reaction is enabled by using (iodoethynyl)trimethylsilane as a radical initiator and iodide source. The 1,2-difunctionalization affords alkenyl iodides, which are versatile building blocks for the construction of tri-substituted alkene derivatives.

中文翻译:

炔烃 的无催化剂分子间反式碘烷基化

我们报道了炔烃与一系列α-羰基化合物的第一个无催化剂和反式选择的碘烷基化反应。通过使用(碘乙炔基)三甲基硅烷作为自由基引发剂和碘化物源,可以实现这种前所未有的三组分碘代烷基化反应。1,2-双官能化提供烯基碘化物,其是用于构建三取代的烯烃衍生物的通用结构单元。
更新日期:2018-01-11
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