Abstract

The iron(III) triflate catalyzed cyclization reaction of phenols and ketones is described; the reaction provides a direct approach to 4H-chromene derivatives. 4H-Chromene is an important structural fragment of many pharmaceuticals, natural products, and functional materials. The 4H-chromene synthetic protocol possesses many advantages, such as using readily available and inexpensive starting materials and a non-toxic catalyst, high selectivity, and operational simplicity, which offer­ attractive industrial prospects from the point of view of green and sustainable chemistry.

The iron(III) triflate catalyzed cyclization reaction of phenols and ketones is described; the reaction provides a direct approach to 4H-chromene derivatives. 4H-Chromene is an important structural fragment of many pharmaceuticals, natural products, and functional materials. The 4H-chromene synthetic protocol possesses many advantages, such as using readily available and inexpensive starting materials and a non-toxic catalyst, high selectivity, and operational simplicity, which offer­ attractive industrial prospects from the point of view of green and sustainable chemistry.

中文翻译：

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通过Fe（OTf）3-催化的苯酚和酮的环化反应高效合成功能化的4H-Chromenes

摘要

描述了三氟甲磺酸铁（III）催化苯酚和酮的环化反应；该反应提供了直接反应4 H-色烯衍生物的方法。4 H-铬烯是许多药物，天然产物和功能材料的重要结构片段。4 H-色烯合成方案具有许多优点，例如使用容易获得且便宜的起始原料和无毒催化剂，高选择性和操作简便性，从绿色和可持续化学的角度来看，这提供了诱人的工业前景。

描述了三氟甲磺酸铁（III）催化苯酚和酮的环化反应；该反应提供了直接反应4 H-色烯衍生物的方法。4 H-铬烯是许多药物，天然产物和功能材料的重要结构片段。4 H-色烯合成方案具有许多优点，例如使用容易获得且便宜的起始原料和无毒催化剂，高选择性和操作简便性，从绿色和可持续化学的角度来看，这提供了诱人的工业前景。