We designed and synthesized an activatable near-infrared (NIR) fluorescent probe for γ-glutamyltransferase, based on an asymmetric silicon rhodamine scaffold with an optimized equilibrium of intramolecular spirocyclization. The synthesized probe exhibits dramatic NIR fluorescence activation and, in combination with previously reported probes, enables discrimination of tumors with different enzymatic profiles.

中文翻译：

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基于罗丹明硅的近红外荧光探针，用于γ-谷氨酰转移酶

我们设计和合成了一种基于γ-谷氨酰转移酶的可活化近红外（NIR）荧光探针，该探针基于不对称硅若丹明支架，并具有分子内螺环化的最佳平衡。合成的探针显示出显着的NIR荧光激活，并且与以前报道的探针结合使用，可以区分具有不同酶促分布图的肿瘤。