Industrial synthesis of enantiopure compounds is nowadays heavily based on the separation of racemates through crystallization processes. Although the application of ultrasound in solution crystallization processes (sonocrystallization) has become a promising emerging technology, offering several benefits (e.g. reduction of the induction time and narrowing of the metastable zone width, control over the product size, shape and polymorphic modification), little attention has been paid so far to the effects of ultrasound on chiral crystallization processes. Several recent studies have reported on the application of acoustic energy to crystallization processes that separate enantiomers, ranging from classical (diastereomeric) resolution and preferential crystallization to new and emerging processes such as attrition-enhanced deracemization (Viedma ripening). A variety of interesting effects have been observed, which include among others, enhanced crystallization yield with higher enantiomeric purity crystals, spontaneous mirror symmetry breaking crystallization, formation of metastable conglomerate crystals and enhanced deracemization rates. The objective of this review is to provide an overview of the effects of ultrasound on chiral crystallization and outline several aspects of interest in this emerging field.

如今，对映纯化合物的工业合成很大程度上取决于通过结晶过程分离外消旋物。尽管超声在溶液结晶过程（超声波结晶）中的应用已成为一种有前途的新兴技术，但它具有多种优势（例如减少诱导时间和缩小亚稳区域的宽度，控制产品的尺寸，形状和多晶型物的修饰，到目前为止，很少有人关注超声波对手性结晶过程的影响。最近的一些研究报道了声能在分离对映异构体的结晶过程中的应用，从经典的（非对映异构体）拆分和优先结晶到新兴的过程，例如损耗增强的除铁（Viedma成熟）。观察到了许多有趣的效果，其中包括：具有较高对映体纯度的晶体提高了结晶产率，自发的镜像对称性破坏了结晶，形成了亚稳态的团聚体晶体以及提高了脱团速率。