An air‐stable and readily accessible ruthenium dihydride complex catalyses aldehyde hydrogenation under neutral conditions. A high activity has been shown in a number of examples, and solvent‐free conditions are also applicable, which favours industrial‐scale applications. The catalyst has also been demonstrated to be active at low catalyst loadings for the reductive amination of aldehydes under mildly acidic conditions. A number of examples of chemoselectivity challenges are also presented in which the catalyst does not reduce carbon−halogen groups, alkene or ketone functionality. The advantage of using the pre‐formed complex, Triphos‐Ru(CO)H₂ (1), over in situ formed catalysts from Triphos and Ru(acac)₃ (acac=acetylacetonate) is also shown in terms of both chemoselectivity and activity, in particular this can be seen if low reaction temperatures are used.

中文翻译：

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三苯钌催化剂对醛的氢化和还原胺化作用

空气稳定且易于获取的二氢化钌配合物在中性条件下催化醛加氢。在许多示例中都显示出很高的活性，并且还可以采用无溶剂条件，这有利于工业规模的应用。还已经证明该催化剂在低催化剂负载量下具有活性，用于在中等酸性条件下对醛进行还原胺化。还提出了许多化学选择性挑战的例子，其中催化剂不还原碳-卤素基团，烯烃或酮官能度。与Triphos和Ru（acac）₃原位形成的催化剂相比，使用预制的络合物Triphos-Ru（CO）H ₂（1）的优势 （acac ＝乙酰丙酮化物）（acac ＝乙酰丙酮化物）也以化学选择性和活性表示，特别是如果使用低反应温度可以看出。